Fyn Antibody (E-12): sc-271294
- Fyn Antibody (E-12) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-80 mapping at the N-terminus of Fyn of human origin
- recommended for detection of Fyn of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- See Fyn (15): sc-434 for Fyn antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Fyn Antibody (E-12) for WB applications. These reagents are now offered in bundles with Fyn Antibody (E-12) (see ordering information below).
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Fyn Antibody (E-12) is a mouse monoclonal IgG2b antibody that detects Fyn in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fyn is a member of the Src family of non-receptor tyrosine kinases, which play a crucial role in various cellular processes, including T-cell receptor signaling, cell proliferation, and differentiation. Fyn protein is primarily localized in the cytoplasm and can translocate to the plasma membrane upon activation, which is essential for mediating signaling pathways that regulate immune responses. This dynamic localization allows Fyn to interact with specific proteins involved in T-cell activation, such as the T-cell receptor complex, thereby influencing downstream signaling cascades that are vital for effective immune responses. Anti-Fyn antibody (E-12) is an invaluable tool for researchers studying the intricate mechanisms of T-cell signaling and the broader implications of Src family kinases in cellular regulation and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fyn Antibody (E-12) References:
- Fyn kinase is required for optimal humoral responses. | Chaimowitz, NS., et al. 2013. PLoS One. 8: e60640. PMID: 23593269
- FYNagling divergent adhesive functions for Fyn in keratinocytes. | Fenton, SE. and Denning, MF. 2015. Exp Dermatol. 24: 81-5. PMID: 24980626
- Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. | Kaufman, AC., et al. 2015. Ann Neurol. 77: 953-71. PMID: 25707991
- Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity. | Zhang, S., et al. 2016. Cell Death Differ. 23: 52-63. PMID: 26001218
- An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons. | Jin, DZ., et al. 2017. eNeuro. 4: PMID: 28948209
- Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development. | St Clair, RM., et al. 2018. FEBS J. 285: 72-86. PMID: 29091353
- Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. | Kant, S., et al. 2020. Mol Cancer Ther. 19: 1415-1422. PMID: 32430486
- Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. | Tang, SJ., et al. 2020. Acta Neuropathol Commun. 8: 96. PMID: 32611392
- Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation. | Taleski, G., et al. 2021. J Biol Chem. 296: 100237. PMID: 33380425
- FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-cadherin. | Kizhatil, K., et al. 2023. bioRxiv.. PMID: 37886565
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fyn Antibody (E-12) | sc-271294 | 200 µg/ml | $322.00 | |||
Fyn Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-534919 | 200 µg Ab; 40 µg BP | $361.00 | |||
Fyn Antibody (E-12): m-IgG2b BP-HRP Bundle | sc-549315 | 200 µg Ab; 10 µg BP | $361.00 |