fetuin-A Antibody (H-11): sc-137102

fetuin-A Antibody (H-11) is a mouse monoclonal IgG2a antibody that detects fetuin-A in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fetuin-A, also known as α-2-HS-glycoprotein, is a secreted plasma protein primarily produced in hepatocytes, monocytes, and macrophages, and plays a crucial role in maintaining serum calcium homeostasis and mineralization by preferentially binding to calcium and barium ions in the bloodstream. Anti-fetuin-A antibody (H-11) is particularly useful in studying inflammation, as fetuin-A levels significantly decrease during tissue injury, leading to its association with macrophage membranes. The membrane-bound form of fetuin-A enhances the uptake of cationic small molecules into activated macrophages, thereby facilitating mechanisms that deactivate these immune cells. Structurally, biologically active fetuin-A is derived from a precursor protein that undergoes cleavage at the amino terminus, resulting in two chains linked by a single disulfide bond, which is essential for its functional properties. The ability of fetuin-A to act as an acute phase anti-inflammatory mediator underscores its significance in regulating the innate immune response, making fetuin-A (H-11) monoclonal antibody a valuable tool for researchers studying inflammation and immune regulation.

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fetuin-A Antibody (H-11) References:

1. Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes.  |  Ochieng, J., et al. 2018. Int J Mol Sci. 19: PMID: 30060600
2. Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis.  |  Pan, X., et al. 2020. PLoS One. 15: e0229776. PMID: 32134969
3. Effects of fetuin-A with diverse functions and multiple mechanisms on human health.  |  Icer, MA. and Yıldıran, H. 2021. Clin Biochem. 88: 1-10. PMID: 33245873
4. Tissue chaperoning-the expanded functions of fetuin-A beyond inhibition of systemic calcification.  |  Rudloff, S., et al. 2022. Pflugers Arch. 474: 949-962. PMID: 35403906
5. Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications.  |  Chekol Abebe, E., et al. 2022. Clin Cosmet Investig Dermatol. 15: 595-607. PMID: 35422648
6. Causal association pathways between fetuin-A and kidney function: a mediation analysis.  |  Bassey, PE., et al. 2022. J Int Med Res. 50: 3000605221082874. PMID: 35435033
7. Influence of Fetuin-A on Chlamydia muridarum Pulmonary Infection.  |  Mahjabeen, F., et al. 2022. Int J Microbiol. 2022: 6082140. PMID: 35498397
8. The structure, biosynthesis, and biological roles of fetuin-A: A review.  |  Chekol Abebe, E., et al. 2022. Front Cell Dev Biol. 10: 945287. PMID: 35923855
9. Fetuin-A peptide inhibits cartilage calcification.  |  Onuora, S. 2023. Nat Rev Rheumatol. 19: 63. PMID: 36627395
10. Fetuin-A and its genetic association with cardiometabolic disease.  |  Al Ali, L., et al. 2023. Sci Rep. 13: 21469. PMID: 38052855

The preferred fetuin-A antibody is fetuin-A Antibody (H-4): sc-133146.