Farnesyl pyrophosphate ammonium salt, in ethanol CAS: 13058-04-3
MF: C15H25O7P2•3NH4
MW: 433.42
An isoprenoid farnesyl donor.

Farnesyl pyrophosphate ammonium salt, in ethanol (CAS 13058-04-3)

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Sinónimo: FPP.3NH4
Solicitud: An isoprenoid farnesyl donor
Número de CAS: 13058-04-3
Pureza: ≥98%
Peso Molecular: 433.42
Fórmula Molecular: C15H25O7P23NH4
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Farnesyl pyrophosphate ammonium salt, in ethanol, is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP has been shown to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. FPP has also been detected in Alzheimer′s patients brains in elevated levels. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: 2 mg/mL in 0.25M ammonium bicarbonate containing 70% ethanol.


References

1. Pompliano, D.L., et al. 1992. Biochemistry. 31: 3800-3807. PMID: 1567835
2. Reiss, Y., et al. 1992. J. Biol. Chem. 267: 6403-6408. PMID: 1556143
3. Gauthaman, K., et al. 2009. Br. J. Pharmacol. 157: 962-973. PMID: 19438511
4. Ye, Y., et al. 2009. FEBS Lett. 583: 2997-3003. PMID: 19716825
5. Mather, A., et al. 2009. Int. J. Biochem. Cell Biol. 41: 561-569. PMID: 18692592
6. Hooff, G.P., et al. 2010. Biochim Biophys Acta.180: 896-905. PMID: 20382260

Uso :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Formulación :
0.25M ammonium bicarbonate containing 70% ethanol
Estado de Materia :
Liquid
Solubilidad :
Soluble in water.
ALMACENAMIENTO :
Store at -20° C
Punto de ebullición :
78° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
1
PubChem CID :
71299715
Número MDL :
MFCD00189688
SMILES :
CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C.N.N.N

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