Factor H Antibody (H-5): sc-166608
- Factor H Antibody (H-5) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 61-360 mapping within an internal region of Factor H of human origin
- Factor H Antibody (H-5) is recommended for detection of Factor H of human origin by WB, IP, IF and ELISA
- Anti-Factor H Antibody (H-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Factor H Antibody (H-5) for WB applications. These reagents are now offered in bundles with Factor H Antibody (H-5) (see ordering information below).
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Factor H Antibody (H-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Factor H of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Factor H (H-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Factor H plays a crucial role in regulating the alternative complement pathway, which is essential for the immune response, as Factor H prevents the complement system from attacking the body′s own cells. This regulation is vital because dysregulation can lead to autoimmune diseases and acute renal conditions, highlighting Factor H′s importance in maintaining immune homeostasis. The human complement Factor H gene encodes a 1213 amino acid serum glycoprotein characterized by 20 short consensus repeats (SCRs), each approximately 60 amino acids long, which contribute to Factor H′s multifunctional capabilities. Factor H interacts with various cellular receptors and glycosaminoglycans, further emphasizing Factor H′s role beyond the complement system and potential implications in both health and disease. Factor H deficiencies are commonly associated with acute renal disease, making Factor H a significant target for research and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor H Antibody (H-5) References:
- The human complement factor H: functional roles, genetic variations and disease associations. | Rodríguez de Córdoba, S., et al. 2004. Mol Immunol. 41: 355-67. PMID: 15163532
- Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. | Pickering, MC. and Cook, HT. 2008. Clin Exp Immunol. 151: 210-30. PMID: 18190458
- Complement factor H related proteins in immune diseases. | Skerka, C. and Zipfel, PF. 2008. Vaccine. 26 Suppl 8: I9-14. PMID: 19388158
- Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. | Zaferani, A., et al. 2012. J Biol Chem. 287: 31471-81. PMID: 22815489
- The interaction between factor H and Von Willebrand factor. | Feng, S., et al. 2013. PLoS One. 8: e73715. PMID: 23991205
- An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy. | Nichols, EM., et al. 2015. Kidney Int. 88: 1314-1322. PMID: 26221753
- The Murine Factor H-Related Protein FHR-B Promotes Complement Activation. | Cserhalmi, M., et al. 2017. Front Immunol. 8: 1145. PMID: 28974948
- Complement factor H-deficient mice develop spontaneous hepatic tumors. | Laskowski, J., et al. 2020. J Clin Invest. 130: 4039-4054. PMID: 32369457
- Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein. | Harrison, RES., et al. 2020. ACS Med Chem Lett. 11: 1054-1059. PMID: 32435425
- Common complement factor H polymorphisms are linked with periodontitis in elderly patients. | Salminen, A., et al. 2022. J Periodontol. 93: 1626-1634. PMID: 35315933
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor H Antibody (H-5) | sc-166608 | 200 µg/ml | $322.00 | |||
Factor H Antibody (H-5): m-IgG Fc BP-HRP Bundle | sc-527173 | 200 µg Ab; 10 µg BP | $361.00 | |||
Factor H Antibody (H-5): m-IgG1 BP-HRP Bundle | sc-532546 | 200 µg Ab; 20 µg BP | $361.00 | |||
Factor H Antibody (H-5) AC | sc-166608 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Factor H Antibody (H-5) HRP | sc-166608 HRP | 200 µg/ml | $322.00 | |||
Factor H Antibody (H-5) FITC | sc-166608 FITC | 200 µg/ml | $336.00 | |||
Factor H Antibody (H-5) PE | sc-166608 PE | 200 µg/ml | $349.00 | |||
Factor H Antibody (H-5) Alexa Fluor® 488 | sc-166608 AF488 | 200 µg/ml | $364.00 | |||
Factor H Antibody (H-5) Alexa Fluor® 546 | sc-166608 AF546 | 200 µg/ml | $364.00 | |||
Factor H Antibody (H-5) Alexa Fluor® 594 | sc-166608 AF594 | 200 µg/ml | $364.00 | |||
Factor H Antibody (H-5) Alexa Fluor® 647 | sc-166608 AF647 | 200 µg/ml | $364.00 | |||
Factor H Antibody (H-5) Alexa Fluor® 680 | sc-166608 AF680 | 200 µg/ml | $364.00 | |||
Factor H Antibody (H-5) Alexa Fluor® 790 | sc-166608 AF790 | 200 µg/ml | $364.00 |