EMMPRIN/CD147 Antibody (1.BB.218): sc-71038

EMMPRIN Antibody (1.BB.218) is a mouse monoclonal IgG1 kappa light chain antibody that detects EMMPRIN of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-EMMPRIN antibody (1.BB.218) is available in non-conjugated form. Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, plays a crucial role in regulating matrix remodeling at the epidermal-dermal interface, which is vital for maintaining skin integrity and facilitating wound healing. EMMPRIN is primarily located on the cell surface, where EMMPRIN interacts with fibroblasts to stimulate the production of various matrix metalloproteinases (MMPs), including interstitial collagenase, gelatinase A, and stromelysin-1. These enzymes are essential for tissue remodeling, particularly during processes such as cancer invasion and metastasis, as MMPs degrade extracellular matrix components, allowing for tumor progression and spread. EMMPRIN′s ability to modulate MMP activity underscores EMMPRIN′s importance in both physiological and pathological contexts, making EMMPRIN a significant target for research in cancer biology and tissue repair.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

EMMPRIN/CD147 Antibody (1.BB.218) References:

1. EMMPRIN mediates beta-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes.  |  Siwik, DA., et al. 2008. J Mol Cell Cardiol. 44: 210-7. PMID: 17869266
2. EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction.  |  Seizer, P., et al. 2009. Thromb Haemost. 101: 682-6. PMID: 19350111
3. EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2alpha-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2.  |  Bougatef, F., et al. 2009. Blood. 114: 5547-56. PMID: 19837976
4. Involvement of miR-485-5p in hepatocellular carcinoma progression targeting EMMPRIN.  |  Sun, X., et al. 2015. Biomed Pharmacother. 72: 58-65. PMID: 26054676
5. EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF.  |  Chen, Y., et al. 2015. Oncotarget. 6: 32575-85. PMID: 26416452
6. EMMPRIN Down-regulating miR-106a/b Modifies Breast Cancer Stem-like Cell Properties via Interaction with Fibroblasts Through STAT3 and HIF-1α.  |  Liu, Y., et al. 2016. Sci Rep. 6: 28329. PMID: 27325313
7. Interaction between the Wnt/β-catenin signaling pathway and the EMMPRIN/MMP-2, 9 route in periodontitis.  |  Liu, X., et al. 2018. J Periodontal Res. 53: 842-852. PMID: 29900539
8. CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts.  |  Aoki, M., et al. 2019. BMC Cancer. 19: 912. PMID: 31510956
9. The role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis.  |  Rahat, MA., et al. 2020. Arthritis Res Ther. 22: 240. PMID: 33054815
10. EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells.  |  Feigelman, G., et al. 2024. Front Immunol. 15: 1374088. PMID: 38725999

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EMMPRIN/CD147 Antibody (1.BB.218) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-EMMPRIN/CD147 Antibody (1.BB.218) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EMMPRIN/CD147 Antibody (1.BB.218) Specifications

Alternate Product Name: EMMPRIN

Product Clone Name: 1.BB.218

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: EMMPRIN

Epitope Species: human

Product Reactivity/Detection: EMMPRIN

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for EMMPRIN/CD147 Antibody (1.BB.218): N/A

The preferred EMMPRIN/CD147 antibody is EMMPRIN/CD147 Antibody (8D6): sc-21746.