EBV gp110 Envelope Protein Antibody (5B2): sc-56980

EBV gp110 Envelope Protein Antibody (5B2) is a mouse monoclonal IgG1 antibody that detects EBV gp110 Envelope Protein of Epstein-Barr Virus origin by immunofluorescence (IF). Anti-EBV gp110 Envelope Protein antibody (5B2) is available as the non-conjugated format. The Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a prevalent member of the herpesvirus family, infecting approximately 90% of the global population. While EBV often remains asymptomatic, EBV can lead to infectious mononucleosis, characterized by symptoms such as fatigue, fever, and sore throat. EBV specifically targets B lymphocytes, and EBV′s linear genome circularizes upon entering the host cell, existing as an episome. Notably, EBV is implicated in the development of certain malignancies, including Burkitt lymphoma and nasopharyngeal carcinoma. Glycoprotein 110 (gp110) is a crucial envelope protein expressed during the late stages of the EBV replicative cycle, primarily located in the endoplasmic reticulum. Gp110 plays a vital role in the assembly and egress of the virus, with gp110′s C-terminal tail domain being essential for function, as gp110 may provide critical signals for the assembly and release of EBV. Understanding the structure and function of gp110 is important for developing therapeutic strategies against EBV-related diseases, making EBV gp110 (5B2) monoclonal antibody an invaluable tool for researchers studying this virus and associated pathologies.

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EBV gp110 Envelope Protein Antibody (5B2) References:

1. Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma.  |  Ruf, IK., et al. 1999. Mol Cell Biol. 19: 1651-60. PMID: 10022853
2. Effect of tandem rare codon substitution and vector-host combinations on the expression of the EBV gp110 C-terminal domain in Escherichia coli.  |  Park, SJ., et al. 2002. Protein Expr Purif. 24: 470-80. PMID: 11922764
3. Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.  |  Spender, LC., et al. 2006. J Gen Virol. 87: 2859-2867. PMID: 16963743
4. Serodiagnosis of infectious mononucleosis by using recombinant Epstein-Barr virus antigens and enzyme-linked immunosorbent assay technology.  |  Gorgievski-Hrisoho, M., et al. 1990. J Clin Microbiol. 28: 2305-11. PMID: 2172287
5. Characterization of the restricted component of Epstein-Barr virus early antigens as a cytoplasmic filamentous protein.  |  Luka, J., et al. 1986. J Virol. 58: 748-56. PMID: 2422401
6. Neutralization of Epstein-Barr virus-induced ribonucleotide reductase with antibody to the major restricted early antigen polypeptide.  |  Goldschmidts, WL., et al. 1989. Virology. 170: 330-3. PMID: 2541553
7. Epstein-Barr Viral Antigens Used in the Diagnosis of Nasopharyngeal Carcinoma.  |  Gan, YY., et al. 1996. J Biomed Sci. 3: 159-169. PMID: 11725096
8. HLA-DR polymorphism influences T-cell precursor frequencies to Epstein-Barr virus (EBV) gp110: implications for the association of HLA-DR antigens with rheumatoid arthritis.  |  Toussirot, E., et al. 1999. Tissue Antigens. 54: 146-52. PMID: 10488741
9. Four consecutive arginine residues at positions 836-839 of EBV gp110 determine intracellular localization of gp110.  |  Lee, SK. 1999. Virology. 264: 350-8. PMID: 10562497

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EBV gp110 Envelope Protein Antibody (5B2) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EBV gp110 Envelope Protein Antibody (5B2) Specifications

Alternate Product Name: EBV gp110 Envelope Protein

Product Clone Name: 5B2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: EBV gp110 Envelope Protein

Epitope Species: Epstein-Barr virus

Product Reactivity/Detection: EBV gp110 Envelope Protein

Species Reactivity/Detection: Epstein-Barr Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for EBV gp110 Envelope Protein Antibody (5B2): N/A