Dystrobrevin Antibody (C-6): sc-271874
- Dystrobrevin Antibody (C-6) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 315-347 within an internal region of α-Dystrobrevin of mouse origin
- Dystrobrevin Antibody (C-6) is recommended for detection of all isoforms of α-Dystrobrevin and β-Dystrobrevin of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine and avian
- Anti-Dystrobrevin Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Dystrobrevin Antibody (C-6) for WB applications. These reagents are now offered in bundles with Dystrobrevin Antibody (C-6) (see ordering information below).
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Dystrobrevin Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dystrobrevin across mouse, rat, and human species by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Dystrobrevin antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dystrobrevins are integral components of the dystrophin complex, which plays a crucial role in maintaining the structural integrity of muscle cells; disruption of this complex is linked to Duchenne muscular dystrophy and related disorders. Dystrobrevin is primarily localized to the cytoplasmic side of the sarcolemma and is particularly concentrated at neuromuscular junctions in skeletal muscle, where Dystrobrevin is essential for synapse maturation and normal muscle function. Notably, α-Dystrobrevin undergoes alternative splicing, resulting in the insertion of 57 amino acids that increase its molecular mass in skeletal and cardiac muscle compared to brain and lung tissues. Additionally, α-Dystrobrevin-containing complexes are found in endothelial and smooth muscle cells, while β-Dystrobrevin complexes are localized to the basal region of renal epithelial cells and are also enriched in neurons, particularly at postsynaptic densities. The presence of multiple isoforms, including γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, further highlights the complexity and functional diversity of this protein family, making Dystrobrevin (C-6) antibody an invaluable tool for researchers studying muscle biology and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dystrobrevin Antibody (C-6) References:
- Different dystrophin-like complexes are expressed in neurons and glia. | Blake, DJ., et al. 1999. J Cell Biol. 147: 645-58. PMID: 10545507
- Assembly of multiple dystrobrevin-containing complexes in the kidney. | Loh, NY., et al. 2000. J Cell Sci. 113 (Pt 15): 2715-24. PMID: 10893187
- Cellular and molecular properties of alpha-dystrobrevin in skeletal muscle. | Enigk, RE. and Maimone, MM. 2001. Front Biosci. 6: D53-64. PMID: 11145920
- A novel mechanism for modulating synaptic gene expression: differential localization of alpha-dystrobrevin transcripts in skeletal muscle. | Newey, SE., et al. 2001. Mol Cell Neurosci. 17: 127-40. PMID: 11161474
- Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans. | Gieseler, K., et al. 2001. J Mol Biol. 307: 107-17. PMID: 11243807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dystrobrevin Antibody (C-6) | sc-271874 | 200 µg/ml | $322.00 | |||
Dystrobrevin Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-527302 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dystrobrevin Antibody (C-6): m-IgG1 BP-HRP Bundle | sc-532675 | 200 µg Ab; 20 µg BP | $361.00 | |||
Dystrobrevin Antibody (C-6) AC | sc-271874 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Dystrobrevin Antibody (C-6) HRP | sc-271874 HRP | 200 µg/ml | $322.00 | |||
Dystrobrevin Antibody (C-6) FITC | sc-271874 FITC | 200 µg/ml | $336.00 | |||
Dystrobrevin Antibody (C-6) PE | sc-271874 PE | 200 µg/ml | $349.00 | |||
Dystrobrevin Antibody (C-6) Alexa Fluor® 488 | sc-271874 AF488 | 200 µg/ml | $364.00 | |||
Dystrobrevin Antibody (C-6) Alexa Fluor® 546 | sc-271874 AF546 | 200 µg/ml | $364.00 | |||
Dystrobrevin Antibody (C-6) Alexa Fluor® 594 | sc-271874 AF594 | 200 µg/ml | $364.00 | |||
Dystrobrevin Antibody (C-6) Alexa Fluor® 647 | sc-271874 AF647 | 200 µg/ml | $364.00 | |||
Dystrobrevin Antibody (C-6) Alexa Fluor® 680 | sc-271874 AF680 | 200 µg/ml | $364.00 | |||
Dystrobrevin Antibody (C-6) Alexa Fluor® 790 | sc-271874 AF790 | 200 µg/ml | $364.00 | |||
Dystrobrevin (C-6) Neutralizing Peptide | sc-271874 P | 100 µg/0.5 ml | $69.00 |