DNA pol α Antibody (D-4): sc-373884
- DNA pol α Antibody (D-4) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-31 near the N-terminus of DNA pol α of human origin
- recommended for detection of DNA pol α of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DNA pol α Antibody (D-4) for WB applications. These reagents are now offered in bundles with DNA pol α Antibody (D-4) (see ordering information below).
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DNA pol α Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects DNA polymerase alpha in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DNA polymerase alpha plays a crucial role in DNA replication, particularly in synthesizing RNA-DNA primers necessary for initiating DNA strand synthesis. DNA polymerase alpha (D-4) antibody helps researchers study essential enzyme functions in DNA replication machinery, ensuring accurate and efficient replication processes for genomic stability. DNA polymerase alpha belongs to a larger family of DNA polymerases, including DNA pol δ and ε, but stands unique in laying down initial nucleotides required for DNA synthesis. Anti-DNA polymerase alpha antibody (D-4) enables researchers to investigate cellular proliferation and repair mechanisms, providing insights into molecular pathways that maintain genomic stability and prevent diseases like cancer.
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DNA pol α Antibody (D-4) References:
- Molecular architecture of the mouse DNA polymerase alpha-primase complex. | Mizuno, T., et al. 1999. Mol Cell Biol. 19: 7886-96. PMID: 10523676
- Maize DNA polymerase alpha is phosphorylated by a PCNA-associated cyclin/Cdk complex: effect of benzyladenine. | Gómez Roig, E. and Vázquez-Ramos, JM. 2003. J Plant Physiol. 160: 983-90. PMID: 14593798
- Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta. | Pavlov, YI., et al. 2006. Curr Biol. 16: 202-7. PMID: 16431373
- Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. | Zhu, W., et al. 2007. Genes Dev. 21: 2288-99. PMID: 17761813
- DNA polymerase alpha is associated with replicating SV40 nucleoprotein complexes. | Otto, B. and Fanning, E. 1978. Nucleic Acids Res. 5: 1715-28. PMID: 208060
- Purification and properties of an accessory protein for DNA polymerase alpha/primase. | Goulian, M., et al. 1990. J Biol Chem. 265: 13221-30. PMID: 2165497
- Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties. | Krauss, SW., et al. 1987. J Biol Chem. 262: 3432-5. PMID: 3818650
- Preparation of DNA polymerase alpha X C1C2 by reconstituting DNA polymerase alpha with its specific stimulatory cofactors, C1C2. | Pritchard, CG. and DePamphilis, ML. 1983. J Biol Chem. 258: 9801-9. PMID: 6885771
- DNA replication in vitro by recombinant DNA-polymerase-alpha-primase. | Stadlbauer, F., et al. 1994. Eur J Biochem. 222: 781-93. PMID: 8026492
- Ultrastructural aspects of the DNA polymerase alpha distribution during the cell cycle. | Lattanzi, G., et al. 1998. J Histochem Cytochem. 46: 1435-42. PMID: 9815285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA pol α Antibody (D-4) | sc-373884 | 200 µg/ml | $322.00 | |||
DNA pol α Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-537880 | 200 µg Ab; 10 µg BP | $361.00 | |||
DNA pol α Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-535327 | 200 µg Ab; 40 µg BP | $361.00 | |||
DNA pol α Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-545425 | 200 µg Ab; 20 µg BP | $361.00 | |||
DNA pol α (D-4) Neutralizing Peptide | sc-373884 P | 100 µg/0.5 ml | $69.00 |