DICE1 Antibody (LL7): sc-101232
- DICE1 Antibody (LL7) is a mouse monoclonal IgG1 κ provided at 50 µg/0.5 ml
- raised against recombinant DICE1 of human origin
- recommended for detection of DICE1 of mouse, rat and human origin by IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DICE1 Antibody (LL7). This work is in progress.
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SEE ALSO...
DICE1 Antibody (LL7) is a mouse monoclonal IgG1 antibody that detects DICE1 in mouse, rat, and human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). DICE1, also known as Deleted in Cancer 1, is a critical protein located on chromosome 13q14 and is recognized as a tumor suppressor gene, particularly in non-small cell lung carcinoma. Loss or downregulation of DICE1 expression in most non-small lung carcinomas compared to normal lung tissue is primarily attributed to a loss of heterozygosity of chromosome 13, which is frequently subject to deletions and rearrangements in human lung cancers. The structural integrity of DICE1 is vital, as DICE1 contains a highly conserved DEAD-box motif, which indicates involvement in essential cellular processes such as RNA metabolism and regulation of gene expression. This structural feature underscores DICE1′s role in maintaining cellular homeostasis and highlights potential as a therapeutic target in cancer treatment, where restoring DICE1 function could help reinstate normal regulatory mechanisms disrupted in tumorigenesis. Anti-DICE1 antibody (LL7) serves as an invaluable tool for researchers exploring DICE1′s implications in cancer biology and potential as a biomarker for diagnosis and prognosis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DICE1 Antibody (LL7) | sc-101232 | 50 µg/0.5 ml | $322.00 |