DDX16 Antibody (24): sc-135879

DDX16 Antibody (24) is a mouse monoclonal IgG1 antibody that detects DDX16 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-DDX16 antibody (24) is available as the non-conjugated format. DDX16 protein, also known as DEAD-box protein 16 or DHX16, is a crucial member of the DEAD-box protein family, characterized by the conserved Asp-Glu-Ala-Asp motif and implicated in various cellular processes, particularly RNA metabolism. DDX16 localizes to the nucleus, playing a vital role in pre-mRNA splicing, essential for mRNA maturation and gene expression regulation. DDX16 consists of 1,041 amino acids and contains both a helicase ATP-binding domain and a helicase C-terminal domain, critical for RNA helicase function. DDX16′s importance extends beyond structural attributes; DDX16 is involved in cell cycle progression and has been linked to various diseases, including malignancies and genetic disorders, due to its gene′s location on chromosome 6. DDX16′s interaction with other proteins, such as splicing factors and components of the spliceosome, further underscores its significance in cellular function and highlights its potential as a target for therapeutic intervention in diseases associated with RNA processing dysregulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

DDX16 Antibody (24) References:

1. Identification of a novel human member of the DEAD box protein family.  |  Suk, K., et al. 2000. Biochim Biophys Acta. 1501: 63-9. PMID: 10727850
2. Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters.  |  Shigenari, A., et al. 2004. Immunogenetics. 55: 695-705. PMID: 14673549
3. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.  |  Bellare, P., et al. 2006. RNA. 12: 292-302. PMID: 16428608
4. Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome.  |  Turner, IA., et al. 2006. RNA. 12: 375-86. PMID: 16431982
5. Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.  |  Liu, L., et al. 2007. Nat Struct Mol Biol. 14: 519-26. PMID: 17486100
6. Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.  |  Aronova, A., et al. 2007. RNA. 13: 1437-44. PMID: 17626844
7. Autoregulation of expression of the yeast Dbp2p 'DEAD-box' protein is mediated by sequences in the conserved DBP2 intron.  |  Barta, I. and Iggo, R. 1995. EMBO J. 14: 3800-8. PMID: 7641698
8. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8.  |  Imamura, O., et al. 1998. Nucleic Acids Res. 26: 2063-8. PMID: 9547260

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DDX16 Antibody (24) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DDX16 Antibody (24) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DDX16 Antibody (24) Specifications

Alternate Product Name: DDX16

Product Clone Name: 24

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 256-366

Epitope Target: DDX16

Epitope Species: human

Product Reactivity/Detection: DDX16

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, 20% glycerol and 0.04% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DDX16 Antibody (24): N/A