Molecular structure of Danazol, CAS Number: 17230-88-5
Danazol (CAS 17230-88-5)
See product citations (3)
Application:
Danazol is a modified testosterone gonadotropin inhibitor
CAS Number:
17230-88-5
Purity:
≥98%
Molecular Weight:
337.46
Molecular Formula:
C22H27NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Danazol is a steroid derivative created artificially and functions as a partial agonist of the androgen receptor. It acts by binding to the androgen receptor and modulating gene expression, leading to altered protein synthesis and cellular function. At the molecular level, Danazol interferes with the normal hormonal feedback mechanisms, leading to decreased secretion of gonadotropins and subsequently inhibiting ovulation. Danazol suppresses the pituitary-ovarian axis, resulting in reduced estrogen and progesterone production. These actions collectively contribute to its functional role in experimental applications, particularly in studies related to reproductive endocrinology and hormone regulation.
Danazol (CAS 17230-88-5) References
- Danazol: an antigonadotropic agent in the treatment of pelvic endometriosis. | Lauersen, NH., et al. 1975. Am J Obstet Gynecol. 123: 742-7. PMID: 1200068
- Danazol for the treatment of thrombocytopenia in patients with myelodysplastic syndrome. | Chan, G., et al. 2002. Am J Hematol. 71: 166-71. PMID: 12410570
- Effects of danazol on endothelial cell function and angiogenesis. | Thomas, GW., et al. 2007. Fertil Steril. 88: 1065-70. PMID: 17382938
- Danazol-beta-cyclodextrin binary system: a potential application in emergency contraception by the oral route. | Jadhav, GS., et al. 2007. AAPS PharmSciTech. 8: Article 35. PMID: 17622113
- Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model. | Zhang, X., et al. 2008. Hum Reprod. 23: 2024-30. PMID: 18552364
- Danazol treatment for paroxysmal nocturnal hemoglobinuria. | Murakawa, M., et al. 1990. Jpn J Med. 29: 417-22. PMID: 2273626
- In vitro effect of danazol on endometrioma cells in culture. | Ollivierre, BA., et al. 2014. J Reprod Med. 59: 13-6. PMID: 24597280
- Danazol has potential to cause PKC translocation, cell cycle dysregulation, and apoptosis in breast cancer cells. | Deka, SJ., et al. 2017. Chem Biol Drug Des. 89: 953-963. PMID: 27933735
- Danazol therapy renders red cells resistant to osmotic lysis. | Ahn, YS., et al. 1989. FASEB J. 3: 157-62. PMID: 2914627
- Danazol as First-Line Therapy for Myelodysplastic Syndrome. | Colunga-Pedraza, PR., et al. 2018. Clin Lymphoma Myeloma Leuk. 18: e109-e113. PMID: 29268959
- Danazol binding to steroid receptors in human uterine endometrium. | Tamaya, T., et al. 1984. Fertil Steril. 41: 732-5. PMID: 6714450
- Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up. | Barbieri, RL., et al. 1982. Fertil Steril. 37: 737-46. PMID: 7084496
- Danazol treatment and platelet function. | Fraser, IS. and Burridge, J. 1980. Med J Aust. 1: 313-4. PMID: 7393057
- Danazol suspension injected into the uterine cervix of patients with adenomyosis and myoma. Preliminary study. | Takebayashi, T., et al. 1995. Gynecol Obstet Invest. 39: 207-11. PMID: 7789919
- Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis. | Igarashi, M., et al. 1998. Hum Reprod. 13: 1952-6. PMID: 9740456
Inhibitor of:
17-β Estradiol 6, 17β-HSD, AHSP, AKR1CL1, alpha-L-iduronidase, C1s, Choriogonadotropin, Choriogonadotropin Holo c2, CYP2J11, CYP2J9, Erythroid lineage, Estradiol, GnRH-associated peptide, Gonadotropin β, HCG3, HS3ST5, Multimerin-2, NOBOX, Oviductin, SHBG, TPO, and ZP2.Activator of:
Androgen Receptor, Choriogonadotropin, Choriogonadotropin Holo c3, Dia 2, Est1, Factor IX, Inhibin β-A, KiSS-1, and RhCE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Danazol, 100 mg | sc-203021 | 100 mg | $92.00 | |||
Danazol, 250 mg | sc-203021A | 250 mg | $238.00 |