D-myo-Inositol 1,3,4-tris-phosphate ammonium salt (CAS 93133-76-7)

D-myo-Inositol 1,3,4-tris-phosphate ammonium salt, a derivative of inositol phosphate, has garnered significant attention in biochemical research due to its crucial role as a second messenger in cellular signaling pathways. This compound, characterized by phosphate groups at the 1, 3, and 4 positions of the inositol ring, serves as a key intermediate in the phosphoinositide signaling cascade. Research has explaind its mechanism of action, wherein it is generated in response to extracellular stimuli through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C enzymes. Once synthesized, D-myo-Inositol 1,3,4-tris-phosphate acts by binding to specific receptors on the endoplasmic reticulum, leading to the release of calcium ions from intracellular stores into the cytoplasm. This calcium release subsequently triggers a variety of downstream cellular responses, including muscle contraction, secretion, and gene expression regulation. Moreover, D-myo-Inositol 1,3,4-tris-phosphate has been instrumental in elucidating the intricacies of calcium signaling pathways and their implications in various physiological processes. Researchers have utilized this compound as a molecular tool to study the roles of calcium signaling in cellular physiology, neuronal function, and synaptic plasticity. Furthermore, investigations into its interactions with other signaling molecules and proteins have provided valuable insights into the regulation of cellular responses to environmental cues. Overall, the pivotal role of D-myo-Inositol 1,3,4-tris-phosphate ammonium salt in cellular signaling underscores its importance as a versatile research tool in the field of molecular and cellular biology.