Cytokeratin 17 Antibody (Ks17.E3): sc-101461

Cytokeratin 17 Antibody (Ks17.E3) is a mouse monoclonal IgG2b antibody that detects Cytokeratin 17 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 17 is a crucial member of the Cytokeratin subfamily of intermediate filament proteins, consisting of 432 amino acids, and is predominantly expressed in the basal cells of complex epithelia, including the nail bed, hair follicle, and sebaceous glands. Anti-Cytokeratin 17 antibody (Ks17.E3) plays a vital role in studying protein regulation of cell growth and size through interactions with adaptor protein 14-3-3-sigma, which is essential for mediating protein synthesis. Notably, mutations in the gene encoding Cytokeratin 17 can lead to impaired protein translation and reduced size of skin keratinocytes, which correlates with decreased Akt/mTOR signaling activity. Cytokeratin 17 monoclonal antibody (Ks17.E3) serves as a valuable tool for identifying cervical stem cells and studying various pathologies, including squamous cell carcinoma of the larynx, respiratory syncytial virus infections, and transitional cell carcinomas of the human urinary tract.

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Cytokeratin 17 Antibody (Ks17.E3) References:

1. Cytokeratin 17 is expressed in cells infected with respiratory syncytial virus via NF-kappaB activation and is associated with the formation of cytopathic syncytia.  |  Domachowske, JB., et al. 2000. J Infect Dis. 182: 1022-8. PMID: 10979895
2. Multivariate analyses of Ki-67, cytokeratin 13 and cytokeratin 17 in diagnosis and prognosis of oral precancerous lesions.  |  Yagyuu, T., et al. 2015. J Oral Pathol Med. 44: 523-31. PMID: 25243470
3. Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis.  |  Kim, HS., et al. 2015. Int J Clin Exp Pathol. 8: 5695-701. PMID: 26191283
4. Cytokeratin 13, Cytokeratin 17, Ki-67 and p53 Expression in Upper Layers of Epithelial Dysplasia Surrounding Tongue Squamous Cell Carcinoma.  |  Matsuhira, A., et al. 2015. Bull Tokyo Dent Coll. 56: 223-31. PMID: 26657521
5. Effect of cytokeratin 17 on retinal pigment epithelium degeneration and choroidal neovascularization.  |  Shen, Y., et al. 2016. Int J Ophthalmol. 9: 363-8. PMID: 27158603
6. Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma.  |  Leblebici, C., et al. 2017. Oncol Lett. 13: 2539-2548. PMID: 28454431
7. Distribution of Cytokeratin 17 in the Parenchymal Elements of Rat's Submandibular Glands Subjected to Fractionated Radiotherapy.  |  Hassan, SS., et al. 2020. Eur J Dent. 14: 440-447. PMID: 32590870
8. Antimicrobial peptide nisin induces spherical distribution of macropinocytosis-like cytokeratin 5 and cytokeratin 17 following immediate derangement of the cell membrane.  |  Kitagawa, N. 2022. Anat Cell Biol. 55: 190-204. PMID: 34903675
9. Enhancing upper tract urothelial carcinoma diagnosis: Utility of cytokeratin 17 and CK20/CD44/p53 immunohistochemical panel.  |  Irwin, T., et al. 2024. Hum Pathol. 146: 43-48. PMID: 38593961
10. Cytokeratin 17 expression is commonly observed in keratinocytic skin tumours and controls tissue homeostasis impacting human papillomavirus protein expression.  |  Hasche, D., et al. 2024. Br J Dermatol. 191: 949-963. PMID: 38878280

The preferred Cytokeratin 17 antibody is Cytokeratin 17 Antibody (E-4): sc-393002.