cyclin A Antibody (E70.1): sc-53231
- cyclin A Antibody (E70.1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against bovine cyclin A
- recommended for detection of cyclin A of mouse, rat, human and bovine origin by WB and IP
- See cyclin A (B-8): sc-271682 for cyclin A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for cyclin A Antibody (E70.1) for WB applications. This reagent is now offered in a bundle with cyclin A Antibody (E70.1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Cyclin A Antibody (E70.1) is a mouse monoclonal IgG2a light chain antibody that detects cyclin A in mouse, rat, human, and bovine samples through applications such as western blotting (WB) and immunoprecipitation (IP). Cyclin A plays a pivotal role in the regulation of the eukaryotic cell cycle, particularly during the S phase, where cyclin A is crucial for the proper progression of DNA replication. Cyclin A is primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinase-2 (Cdk2) to form active complexes that drive cell cycle transitions. Nuclear localization of cyclin A is essential for function, as this positioning allows for timely activation of target substrates necessary for cell division. Additionally, cyclin A has been implicated in various cellular processes, including cell transformation, and interacts with key regulatory proteins such as E1A, transcription factors DRTF1 and E2F, and the retinoblastoma protein, p110. Anti-cyclin A antibody (E70.1) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation and transformation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin A Antibody (E70.1) References:
- Inhibition of cyclin A gene expression in human B cells by an immunosuppressant mizoribine. | Hirohata, S., et al. 2000. Clin Exp Immunol. 120: 448-53. PMID: 10844522
- DNA damage leads to a Cyclin A-dependent delay in metaphase-anaphase transition in the Drosophila gastrula. | Su, TT. and Jaklevic, B. 2001. Curr Biol. 11: 8-17. PMID: 11166174
- Cyclin A in cell cycle control and cancer. | Yam, CH., et al. 2002. Cell Mol Life Sci. 59: 1317-26. PMID: 12363035
- The A-type cyclins and the meiotic cell cycle in mammalian male germ cells. | Wolgemuth, DJ., et al. 2004. Int J Androl. 27: 192-9. PMID: 15271198
- Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex. | De Vivo, M., et al. 2006. Proteins. 62: 89-98. PMID: 16292742
- Prognostic significance of cyclin A in gastric cancer. | Mrena, J., et al. 2006. Int J Cancer. 119: 1897-901. PMID: 16708383
- Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes. | Nguyen, CL. and Münger, K. 2008. Virology. 380: 21-5. PMID: 18718623
- A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway. | Ming, P., et al. 2016. Oncotarget. 7: 41843-41856. PMID: 27259234
- Cyclin A-CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry. | Ng, LY., et al. 2023. J Biol Chem. 299: 102957. PMID: 36717077
- Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4. | Shimizu, M., et al. 1998. Exp Cell Res. 239: 93-103. PMID: 9511728
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin A Antibody (E70.1) | sc-53231 | 200 µg/ml | $322.00 | |||
cyclin A Antibody (E70.1): m-IgGκ BP-HRP Bundle | sc-520962 | 200 µg Ab, 40 µg BP | $361.00 |