CRP Antibody (ML-12): sc-73864

CRP Antibody (ML-12) is a mouse monoclonal IgG2b antibody that detects C-reactive protein (CRP) in mouse and rat samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CRP is a crucial acute-phase protein produced primarily by liver epithelial cells in response to inflammation, and CRP levels can rise dramatically during acute inflammatory states, making CRP an important biomarker for various diseases. CRP is characterized by a cyclic pentameric structure that allows for calcium-dependent ligand binding, which is essential for CRP function in the immune response. Notably, CRP interacts with several specific proteins, including Fc gamma receptors, which facilitate the opsonization of pathogens, enhancing their recognition and clearance by phagocytic cells. This interaction underscores CRP′s vital role in the host defense system, as CRP not only aids in the identification of foreign particles but also modulates the immune response during inflammation. Anti-CRP antibody (ML-12) is an invaluable tool for researchers studying the dynamics of inflammation and immune responses in various experimental settings.

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CRP Antibody (ML-12) References:

1. Diagnostic implications of C-reactive protein.  |  Zimmerman, MA., et al. 2003. Arch Surg. 138: 220-4. PMID: 12578424
2. C-reactive protein, stroke, and statins.  |  Angerio, AD., et al. 2007. Crit Care Nurs Q. 30: 161-5. PMID: 17356357
3. C-reactive protein: how conformational changes influence inflammatory properties.  |  Eisenhardt, SU., et al. 2009. Cell Cycle. 8: 3885-92. PMID: 19887916
4. C-reactive protein and high-sensitivity C-reactive protein: an update for clinicians.  |  Windgassen, EB., et al. 2011. Postgrad Med. 123: 114-9. PMID: 21293091
5. C-reactive protein as a biomarker for urological cancers.  |  Saito, K. and Kihara, K. 2011. Nat Rev Urol. 8: 659-66. PMID: 22025173
6. C-reactive protein is elevated in schizophrenia.  |  Dickerson, F., et al. 2013. Schizophr Res. 143: 198-202. PMID: 23218564
7. C-reactive protein levels in hereditary angioedema.  |  Hofman, ZL., et al. 2014. Clin Exp Immunol. 177: 280-6. PMID: 24588117
8. C-reactive protein after stroke in arterial hypertension.  |  Berezin, AE. and Lisovaya, OA. 2014. Asian Cardiovasc Thorac Ann. 22: 551-7. PMID: 24867029
9. C-reactive protein kinetics after major surgery.  |  Santonocito, C., et al. 2014. Anesth Analg. 119: 624-629. PMID: 24878684
10. Interference of C-reactive protein with clotting times.  |  Devreese, KM., et al. 2015. Clin Chem Lab Med. 53: e141-5. PMID: 25324454

The preferred CRP antibody is CRP Antibody (26D7): sc-69770.