CNTF Antibody (G-7): sc-166272

CNTF Antibody (G-7) is a mouse monoclonal IgG1 antibody that detects ciliary neurotrophic factor (CNTF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CNTF is a crucial neuropoietic cytokine that plays a significant role in promoting the survival and differentiation of various cell types, including sensory, sympathetic, and motor neurons, which is vital for maintaining the integrity of the nervous system. CNTF (G-7) antibody targets proteins primarily located in the central nervous system and peripheral tissues, where CNTF exerts effects by binding to the CNTF receptor complex, which consists of CNTFRα, a specific chain for CNTF, and a heterodimer of the gp130 chain and LIFRβ chain. This receptor complex is essential for activating downstream signaling pathways that lead to neuronal survival and regeneration. Notably, CNTF has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), highlighting its importance in neurodegenerative diseases. Research indicates that while mice lacking CNTF exhibit certain deficits, those with a homozygous null mutation in the CNTFRα gene face severe motor neuron deficits and perinatal mortality, suggesting that CNTF and its receptor are critical for the development of the neonatal nervous system. Anti-CNTF antibody (G-7) serves as an invaluable tool for researchers studying neuronal health and disease mechanisms, providing insights into the therapeutic potential of targeting this cytokine in neurodegenerative conditions.

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CNTF Antibody (G-7) References:

1. Intracompartmental delivery of CNTF as therapy for Huntington's disease and retinitis pigmentosa.  |  Emerich, DF. and Thanos, CG. 2006. Curr Gene Ther. 6: 147-59. PMID: 16475952
2. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.  |  Watt, MJ., et al. 2006. Nat Med. 12: 541-8. PMID: 16604088
3. Overexpression of CNTF in Mesenchymal Stem Cells reduces demyelination and induces clinical recovery in experimental autoimmune encephalomyelitis mice.  |  Lu, Z., et al. 2009. J Neuroimmunol. 206: 58-69. PMID: 19081144
4. CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium.  |  Li, R., et al. 2011. PLoS One. 6: e23148. PMID: 21912637
5. CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells.  |  Rhee, KD., et al. 2013. Proc Natl Acad Sci U S A. 110: E4520-9. PMID: 24191003
6. Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo.  |  Jeong, KH., et al. 2015. PLoS One. 10: e0121803. PMID: 25799580
7. Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF.  |  Jia, C., et al. 2019. Exp Neurol. 312: 20-32. PMID: 30408465
8. NGF and CNTF expression and regulation mechanism by miRNA in acute paralytic strabismus.  |  Liu, H., et al. 2020. Int Ophthalmol. 40: 975-984. PMID: 31925656
9. Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR.  |  Rafii, P., et al. 2024. J Biol Chem. 300: 107251. PMID: 38569939
10. Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases.  |  Lindsay, RM. 1996. Ciba Found Symp. 196: 39-48; discussion 48-53. PMID: 8866127

The preferred CNTF antibody is CNTF Antibody (A-11): sc-25286.