Molecular structure of Chk2 Inhibitor, CAS Number: 724708-21-8
Chk2 Inhibitor Inhibitor (CAS 724708-21-8)
Alternate Names:
5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidine)-3,4,5,10-2H-azepino[3,4-b]indol-1-one
Application:
Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest
CAS Number:
724708-21-8
Purity:
≥95%
Molecular Weight:
295.3
Molecular Formula:
C15H13N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Chk2 Inhibitor is an indoloazepine checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest. Checkpoint kinase 2 is activated upon DNA damage or genomic instability which eventually causes apoptosis. Mechanistic studies show that Chk2 inhibitor causes autophosphorylation of Chk2 at Thr68 and targets ATP binding pockets of Chk2. Further studies demonstrate that Chk2 inhibitors also affect interleukin-2 (IL-2), TNF-α, MEK-1, and GSK-3 β.
Chk2 Inhibitor Inhibitor (CAS 724708-21-8) References
- Inhibition of cytokine production by hymenialdisine derivatives. | Sharma, V., et al. 2004. J Med Chem. 47: 3700-3. PMID: 15214798
- Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. | Sharma, V. and Tepe, JJ. 2004. Bioorg Med Chem Lett. 14: 4319-21. PMID: 15261294
- The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1. | Yeh, YH., et al. 2009. Oncogene. 28: 1366-78. PMID: 19151762
- PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. | Carrozza, MJ., et al. 2009. DNA Repair (Amst). 8: 1264-72. PMID: 19717351
- Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. | Jobson, AG., et al. 2009. J Pharmacol Exp Ther. 331: 816-26. PMID: 19741151
Inhibitor of:
Chk1, Chk2, MEK-1, and PNK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk2 Inhibitor, 500 µg | sc-203885 | 500 µg | $458.00 |