CEL Antibody (G-12): sc-377130
- CEL Antibody (G-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a peptide mapping within an internal region of CEL of human origin
- recommended for detection of CEL long and short isoforms of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CEL Antibody (G-12) for WB and IHC(P) applications. These reagents are now offered in bundles with CEL Antibody (G-12) (see ordering information below).
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CEL Antibody (G-12) is a mouse monoclonal IgG1 antibody that detects carboxyl ester lipase (CEL) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CEL antibody (G-12) plays a crucial role in understanding the function of CEL, which is essential for lipid metabolism and the regulation of lipoprotein levels in the body. CEL (G-12) antibody enables detection of CEL primarily produced in the pancreas and lactating mammary gland, but also found in the liver, macrophages, and the vessel wall, highlighting its importance in various physiological processes. CEL is known for its ability to hydrolyze a wide range of lipid substrates, including cholesteryl esters and phospholipids, which are vital for maintaining cellular lipid homeostasis and preventing atherosclerosis. The enzyme′s active site features a catalytic triad composed of serine, histidine, and aspartate, which is critical for its enzymatic activity. CEL monoclonal antibody (G-12) helps researchers gain insights into CEL′s role in lipid metabolism and its potential implications in metabolic disorders and cardiovascular diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CEL Antibody (G-12) References:
- Carboxyl ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice. | Howles, PN., et al. 1999. Am J Physiol. 277: G653-61. PMID: 10484391
- Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. | Kodvawala, A., et al. 2005. J Biol Chem. 280: 38592-8. PMID: 16166077
- Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. | Miller, R. and Lowe, ME. 2008. J Nutr. 138: 927-30. PMID: 18424603
- Pancreatic function in carboxyl-ester lipase knockout mice. | Vesterhus, M., et al. 2010. Pancreatology. 10: 467-76. PMID: 20720448
- Reverse cholesterol transport is elevated in carboxyl ester lipase-knockout mice. | Camarota, LM., et al. 2011. FASEB J. 25: 1370-7. PMID: 21212359
- The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. | El Jellas, K., et al. 2018. J Biol Chem. 293: 19476-19491. PMID: 30315106
- Identification of a Novel Mutation in Carboxyl Ester Lipase Gene in a Patient with MODY-like Diabetes. | Kondoh, T., et al. 2022. Tohoku J Exp Med. 256: 37-41. PMID: 35082198
- Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas. | Brekke, RS., et al. 2024. Hum Mol Genet. 33: 1001-1014. PMID: 38483348
- The MODY-Causing Mutation of the Human Carboxyl Ester Lipase Gene (CEL) Triggers Chronic Pancreatitis but not Diabetes in Mice. | Gravdal, A., et al. 2025. Gastroenterology.. PMID: 39956334
- Carboxyl ester lipase (bile salt-stimulated lipase), colipase, lipase, and phospholipase A2 levels in pancreatic enzyme supplements. | Sternby, B. and Nilsson, A. 1997. Scand J Gastroenterol. 32: 261-7. PMID: 9085464
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CEL Antibody (G-12) | sc-377130 | 200 µg/ml | $322.00 | |||
CEL Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-540696 | 200 µg Ab; 10 µg BP | $361.00 | |||
CEL Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-542305 | 200 µg Ab; 20 µg BP | $361.00 | |||
CEL (G-12) Neutralizing Peptide | sc-377130 P | 100 µg/0.5 ml | $69.00 |