Cefoperazone sodium (CAS 62893-20-3)

Cefoperazone Sodium, a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic, is noteworthy for its extensive application in microbiological research and bacterial culture studies. Unlike many other antibiotics, Cefoperazone Sodium is particularly resistant to beta-lactamase enzymes, making it effective against a wide range of Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which are essential for maintaining the structural integrity of the bacterial cell wall. This inhibition leads to the weakening and eventual rupture of the cell wall, culminating in bacterial cell death. Cefoperazone Sodium is frequently used for selecting bacterial strains in genetic engineering and molecular biology experiments. Its resistance to beta-lactamase degradation enables researchers to employ it in environments where other beta-lactam antibiotics might fail. Additionally, its broad-spectrum activity is in studying polymicrobial cultures and in identifying and isolating bacteria that are resistant to other cephalosporins or penicillins.