CD4 Antibody (RIV6): sc-52385

CD4 Antibody (RIV6) is a mouse monoclonal IgG2a kappa light chain antibody specifically developed to recognize the human CD4 protein, also known as T4 or Leu 3. Anti-CD4 antibody (RIV6) targets an epitope located on the extracellular domain of CD4, a membrane glycoprotein consisting of four immunoglobulin-like domains. CD4 plays a pivotal role in the immune system by serving as a co-receptor for the T cell receptor (TCR), thereby enhancing the binding affinity between the TCR and class II MHC molecules presented by antigen-presenting cells. This interaction is crucial for effective T cell activation and the subsequent immune response. Additionally, CD4 functions as a receptor for HIV, making CD4 an important target for studies related to viral entry and immune evasion. CD4 monoclonal antibody (RIV6) is recommended for immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM) assays. Anti-CD4 antibody (RIV6) demonstrates reactivity with CD4 proteins from mouse, rat, and human species, allowing for broad use in various research models. Beyond T helper cells, CD4 is also expressed on cortical cells, mature medullary thymocytes, microglial cells, and dendritic cells, highlighting CD4′s significance in multiple facets of the immune system. CD4 monoclonal antibody (RIV6) enables researchers to investigate the functions and interactions of CD4 in immune regulation, T cell development, and pathogen interactions, providing valuable insights into both normal immune function and disease mechanisms.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.