CD4 Antibody (EDU-2): sc-51544

CD4 Antibody (EDU-2) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect CD4 protein, also known as T4 or Leu 3, in human samples. Raised against human T-lymphocytes, anti-CD4 antibody (EDU-2) is recommended for use in flow cytometry (FCM), ensuring reliable detection of CD4 in various experimental settings. CD4 is a membrane-bound glycoprotein composed of four extracellular immunoglobulin-like domains, which are critical for structural integrity and function. These domains facilitate CD4 binding to class II major histocompatibility complex (MHC) molecules on antigen-presenting cells, thereby enhancing interaction between T cell receptor (TCR) and antigens. The structural configuration of CD4 is essential for stabilizing TCR-MHC interaction, which is vital for effective T cell activation and initiation of adaptive immune responses. Additionally, extracellular domains of CD4 serve as the primary receptor for human immunodeficiency virus (HIV), mediating viral entry into host cells and contributing to immune system impairment in HIV-infected individuals. Precise membrane localization of CD4, maintained by structural domains, allows effective participation in immune signaling and cell-cell communication. By targeting structured extracellular regions of CD4, CD4 monoclonal antibody (EDU-2) provides accurate identification and characterization of CD4-positive cells, supporting essential research in immunology, including studies on autoimmune diseases, infectious diseases, and development of immunotherapies.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.