CD4 Antibody (A-1): sc-514571

CD4 Antibody (A-1) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect human CD4 protein, also known as T4 or Leu-3, through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) assays. anti-CD4 antibody (A-1) recognizes an epitope encompassing amino acids 26-396 of human CD4 protein, ensuring effective binding and detection in various experimental contexts. CD4 is a crucial membrane-bound glycoprotein composed of four extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail, which collectively facilitate its role as a co-receptor for the T cell receptor (TCR). The structural configuration of CD4 is essential for its interaction with class II major histocompatibility complex (MHC II) molecules on antigen-presenting cells, enhancing the affinity and stability of the TCR-MHC II complex and thereby promoting effective T cell activation and robust adaptive immune responses. Additionally, the extracellular domains of CD4 are involved in binding to HIV, making CD4 a significant target for studies on viral entry and immune system interactions. Located on the surface of T helper cells, macrophages, dendritic cells, and other immune cells, CD4 plays a pivotal role in coordinating immune responses and maintaining immune system balance. CD4 monoclonal antibody (A-1) enables researchers to investigate expression patterns, structural-functional relationships, and regulatory mechanisms of CD4, providing valuable insights into immune regulation, T cell development, and disease processes. anti-CD4 antibody (A-1) serves as an indispensable tool for advancing our understanding of immune system dynamics and supports the development of targeted therapies and diagnostic tools aimed at modulating immune responses and combating infectious diseases.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.