CD4 Antibody (3H739): sc-70674

CD4 Antibody (3H739) is a rat monoclonal IgG1 antibody developed to detect the human CD4 protein, also known as T4 or Leu-3, across mouse, rat, and human species using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD4 antibody (3H739) targets an epitope raised against rat cells transfected with human CD4, ensuring reliable recognition of the CD4 antigen in various experimental settings. CD4 is a membrane-bound glycoprotein primarily located on the surface of T helper cells, macrophages, dendritic cells, and other immune cells, where CD4 plays a crucial role in the immune response. The strategic placement of CD4 on the cell membrane is essential for CD4′s function as a co-receptor in T cell receptor (TCR) signaling, facilitating the interaction with class II major histocompatibility complex (MHC) molecules on antigen-presenting cells. This interaction enhances the binding affinity between the TCR and antigens, promoting effective T cell activation and robust adaptive immune responses. Additionally, the membrane localization of CD4 allows CD4 to serve as a receptor for HIV, making CD4 a significant target for research on viral entry and immune system interactions. CD4 monoclonal antibody (3H739) is instrumental for researchers studying the expression patterns, cellular localization, and functional dynamics of CD4, thereby contributing to a deeper understanding of immune regulation, T cell development, and disease mechanisms. By utilizing CD4 (3H739) antibody, scientists can explore the critical interactions and pathways involving CD4, advancing the development of targeted therapies and diagnostic tools aimed at modulating immune responses and combating infectious diseases.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.