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CD10 Antibody (97C5) - Immunohistochemistry - Image 293315
CD10 Antibody (97C5): sc-19993. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic and membrane staining of cells in white pulp and cells in red pulp.
CD10 Antibody (97C5): sc-19993. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic and membrane staining of cells in white pulp and cells in red pulp.

CD10 Antibody (97C5): sc-19993

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Datasheets
  • CD10 Antibody (97C5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
  • raised against BV173 Ph1-positive human leukemia
  • recommended for detection of CD10 of human origin by IF, IHC(P) and FCM
  • available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • See CD10 (F-4): sc-46656 for CD10 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD10 Antibody (97C5) for IHC(P) applications. These reagents are now offered in bundles with CD10 Antibody (97C5) (see ordering information below).
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CD10 and Neprilysin Antibodies

CD10 Antibody (97C5) is a mouse monoclonal IgG1 antibody that detects CD10 in human samples through immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD10, also known as the common acute lymphoblastic leukemia antigen (CALLA) and neutral endopeptidase (NEP), is a type II integral membrane glycoprotein that plays a crucial role in regulating various biological processes by acting as a zinc metalloprotease. This enzyme cleaves a range of biologically active peptides, including Angiotensins I and II, which are vital for blood pressure regulation and fluid balance in the body. CD10 expression is prominent in early B and T lymphoid precursors, B blasts, certain granulocytes, bone marrow stromal cells, and specific epithelial cells, including some tumor cell lines. CD10 presence serves as an important marker for diagnosing common acute lymphocytic leukemias and certain lymphomas, making anti-CD10 antibody (97C5) an essential tool for researchers and clinicians aiming to understand and identify these hematological malignancies.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

CD10 Antibody (97C5) References:

  1. CD10 expression in diffuse large B-cell lymphomas does not influence survival.  |  Fabiani, B., et al. 2004. Virchows Arch. 445: 545-51. PMID: 15517363
  2. CD-10 immunostaining differentiates superficial basal cell carcinoma from cutaneous squamous cell carcinoma.  |  Wagoner, J., et al. 2007. Am J Dermatopathol. 29: 555-8. PMID: 18032951
  3. Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions.  |  Mokhtari, M. and Ameri, F. 2014. Adv Biomed Res. 3: 206. PMID: 25371863
  4. Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis.  |  Mishra, D., et al. 2016. Mol Biol Int. 2016: 4328697. PMID: 27965895
  5. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.  |  Su, S., et al. 2018. Cell. 172: 841-856.e16. PMID: 29395328
  6. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Chemoresistance.  |  . 2018. Cancer Discov. 8: 264. PMID: 29420180
  7. A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.  |  Yu, S., et al. 2021. Adv Sci (Weinh). 8: e2101848. PMID: 34363355
  8. Stromal CD10 expression in gastric adenocarcinoma.  |  Aziz, SJ., et al. 2022. J Med Life. 15: 679-684. PMID: 35815076
  9. Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells.  |  Meng, Y., et al. 2023. J Hepatol. 79: 1435-1449. PMID: 37689322
  10. CD10-Positive Lymphoplasmacytic Lymphoma: A Diagnostic Pitfall.  |  Ju, Y., et al. 2025. Clin Lymphoma Myeloma Leuk. 25: 23-25. PMID: 39343717

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CD10 Antibody (97C5)

sc-19993
200 µg/ml
$322.00

CD10 Antibody (97C5): m-IgG Fc BP-HRP Bundle

sc-536635
200 µg Ab; 10 µg BP
$361.00

CD10 Antibody (97C5): m-IgGκ BP-HRP Bundle

sc-533792
200 µg Ab; 40 µg BP
$361.00

CD10 Antibody (97C5): m-IgG1 BP-HRP Bundle

sc-544721
200 µg Ab; 20 µg BP
$361.00

CD10 Antibody (97C5) FITC

sc-19993 FITC
200 µg/ml
$336.00

CD10 Antibody (97C5) PE

sc-19993 PE
200 µg/ml
$349.00

Can CD10 (97C5): sc-19993 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD10 (97C5): sc-19993 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Great IF images with methanolGreat IF images with methanol-fixed LNCaP cells. -SCBT QC
Date published: 2015-04-05
Rated 5 out of 5 by from Produced clear immunoperoxidase cytoplasmicProduced clear immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human spleen tissue. -SCBT QC
Date published: 2015-03-31
Rated 5 out of 5 by from Worked well for paraffinWorked well for paraffin-embedded human peripheral blood lymphocytes. -SCBT QC
Date published: 2015-02-09
Rated 5 out of 5 by from Wonderful FCM data of human peripheral bloodWonderful FCM data of human peripheral blood leukocytes. -SCBT QC
Date published: 2014-03-19
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CD10 Antibody (97C5) is rated 5.0 out of 5 by 4.
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