Caper Antibody (P14): sc-101103

Caper Antibody (P14) is a mouse monoclonal IgG2a antibody that detects Caper in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Caper, also known as splicing factor HCC1 or hepatocellular carcinoma protein 1, plays a crucial role as a transcriptional coactivator for steroid nuclear receptors such as c-Jun, estrogen receptor alpha, and estrogen receptor beta, which are vital for regulating gene expression in response to hormonal signals. Caper is predominantly located in the nucleus, particularly in nuclear speckles, where Caper (P14) monoclonal antibody detects involvement in the pre-mRNA splicing process, a critical step in gene expression that ensures proper maturation of mRNA before translation into proteins. Caper expression in various tissues, including skeletal muscle, lung, brain, and pancreas, highlights anti-Caper antibody (P14) importance in studying diverse biological processes and potential implications in diseases such as cancer, where aberrant splicing can lead to dysfunctional proteins. Anti-Caper antibody (P14) serves as an essential tool for researchers exploring functional dynamics in cellular contexts and interactions with other splicing factors and nuclear receptors.

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Caper Antibody (P14) References:

1. HCC1, the Arabidopsis homologue of the yeast mitochondrial copper chaperone SCO1, is essential for embryonic development.  |  Steinebrunner, I., et al. 2011. J Exp Bot. 62: 319-30. PMID: 21041373
2. CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in Ewing sarcoma cells.  |  Huang, G., et al. 2012. Cancer. 118: 2106-16. PMID: 22009261
3. CAPER: a chromosome-assembled human proteome browsER.  |  Guo, F., et al. 2013. J Proteome Res. 12: 179-86. PMID: 23256906
4. CAPER, a novel regulator of human breast cancer progression.  |  Mercier, I., et al. 2014. Cell Cycle. 13: 1256-64. PMID: 24621503
5. Overexpression of HCC1/CAPERα may play a role in lung cancer carcinogenesis.  |  Chai, Y., et al. 2014. Tumour Biol. 35: 6311-7. PMID: 24643682
6. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC.  |  Kang, YK., et al. 2015. PLoS Genet. 11: e1005116. PMID: 25830341
7. CAPER as a therapeutic target for triple negative breast cancer.  |  Campbell, MC., et al. 2018. Oncotarget. 9: 30340-30354. PMID: 30100993
8. Development of CAPER peptides for the treatment of triple negative breast cancer.  |  Chilewski, SD., et al. 2020. Cell Cycle. 19: 432-447. PMID: 31931653
9. The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging.  |  Titus, MB., et al. 2021. Dev Biol. 473: 15-32. PMID: 33508255
10. HCC1, a Polygalacturonase, Regulates Chlorophyll Degradation via the Ethylene Synthesis Pathway.  |  Liao, Y., et al. 2023. Rice (N Y). 16: 57. PMID: 38071259

The preferred Caper antibody is Caper Antibody (G-10): sc-376531.