Date published: 2026-5-10

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Bupivacaine Free Base (CAS 38396-39-3)

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Alternate Names:
Bupivacaine Free Base is also known as Marcaine and Sensorcaine.
Application:
Bupivacaine Free Base is local anesthetic which binds to the intracellular portion of sodium channels and blocks sodium influx into the nerve cells
CAS Number:
38396-39-3
Molecular Weight:
288.43
Molecular Formula:
C18H28N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bupivacaine Free Base is widely used in biochemical research focusing on the mechanism of sodium channel blockade. This compound is particularly valuable for studies investigating local anesthetic mechanisms at the molecular and cellular levels. Research involving Bupivacaine Free Base often centers on its interaction with voltage-gated sodium channels and its effect on nerve impulse transmission, which is essential for understanding how pain signals are modulated. Additionally, Bupivacaine Free Base is utilized in studies aiming to explore the duration and potency of sodium channel inhibition, providing insights into the differential effects of local anesthetics on sensory and motor neurons. Furthermore, the compound is often used in electrophysiological assays to map the pharmacological profiles of sodium channels across different tissues and species.


Bupivacaine Free Base (CAS 38396-39-3) References

  1. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine.  |  Kohane, DS., et al. 2000. Pharm Res. 17: 1243-9. PMID: 11145230
  2. Identification of the precipitate in alkalinized solutions of mepivacaine and bupivacaine at 37 degrees C.  |  Bigeleisen, PE. and Wempe, M. 2001. J Clin Pharm Ther. 26: 171-3. PMID: 11422599
  3. Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery.  |  Heller, J., et al. 2002. J Control Release. 78: 133-41. PMID: 11772455
  4. In vivo release of bupivacaine from subcutaneously administered oily solution. Comparison with in vitro release.  |  Larsen, DB., et al. 2002. J Control Release. 81: 145-54. PMID: 11992687
  5. In vitro characterization of polyorthoester microparticles containing bupivacaine.  |  Deng, JS., et al. 2003. Pharm Dev Technol. 8: 31-8. PMID: 12665195
  6. On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes.  |  Sun, X. and Garlid, KD. 1992. J Biol Chem. 267: 19147-54. PMID: 1382068
  7. Solid-state NMR studies of pharmaceutical solids in polymer matrices.  |  Lubach, JW., et al. 2004. Anal Bioanal Chem. 378: 1504-10. PMID: 15214410
  8. Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block.  |  Coskuner, I., et al. 2007. Eur J Anaesthesiol. 24: 535-40. PMID: 17241499
  9. The influence of epidural volume extension on spinal block with hyperbaric or plain bupivacaine for Caesarean delivery.  |  Kucukguclu, S., et al. 2008. Eur J Anaesthesiol. 25: 307-13. PMID: 17888192
  10. Local myotoxicity from sustained release of bupivacaine from microparticles.  |  Padera, R., et al. 2008. Anesthesiology. 108: 921-8. PMID: 18431129
  11. The duration of intrathecal bupivacaine mixed with lidocaine.  |  Lee, SJ., et al. 2008. Anesth Analg. 107: 824-7. PMID: 18713891
  12. Prolonged amelioration of experimental postoperative pain by bupivacaine released from microsphere-coated hernia mesh.  |  Ohri, R., et al. 2014. Reg Anesth Pain Med. 39: 97-107. PMID: 24513957
  13. Nanogels with High Loading of Anesthetic Nanocrystals for Extended Duration of Sciatic Nerve Block.  |  Alejo, T., et al. 2021. ACS Appl Mater Interfaces. 13: 17220-17235. PMID: 33821601
  14. Racemisation Of R-Bupivacaine:  A Key Factor In The Integrated And Economic Process For The Production Of Levobupivacaine  |  Marianne Langston, et al. 2000. Org. Proc. Res. Dev. 4: 530–533.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bupivacaine Free Base, 1 g

sc-204657
1 g
$231.00

Bupivacaine Free Base, 5 g

sc-204657A
5 g
$397.00

Bupivacaine Free Base, 25 g

sc-204657B
25 g
$1515.00

Bupivacaine Free Base, 100 g

sc-204657C
100 g
$4162.00