β-Amyloid Antibody (NAB228): sc-32277

β-Amyloid Antibody (NAB228) is a mouse monoclonal IgG2a antibody that detects β-Amyloid in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. β-Amyloid plays a crucial role in the pathogenesis of Alzheimer′s disease, as β-Amyloid is a key component of amyloid plaques that accumulate in the brains of affected individuals. These plaques form from proteolytic cleavage of Amyloid precursor protein (APP), which undergoes alternative splicing to produce different isoforms. β-Amyloid accumulation associates with Alzheimer′s disease, type II diabetes, and Down syndrome, highlighting β-Amyloid′s significance in neurodegenerative processes. β-Amyloid presence in human platelets further underscores β-Amyloid′s potential as a biomarker for these diseases. Understanding β-Amyloid dynamics and interactions with other proteins, such as APLP1 and APLP2, which share structural similarities with APP, is essential for developing therapeutic strategies aimed at mitigating amyloid deposition effects in the brain. Anti-β-Amyloid antibody (NAB228) serves as an invaluable tool for researchers investigating molecular mechanisms underlying these complex diseases.

The preferred β-Amyloid antibody is β-Amyloid Antibody (B-4): sc-28365.