Molecular structure of Benzonatate, CAS Number: 104-31-4
Benzonatate (CAS 104-31-4)
See product citations (2)
Alternate Names:
Benzononantin; Benzononatine; Exangit
Application:
Benzonatate is an anti-tussive chemical used for biochemical research
CAS Number:
104-31-4
Molecular Formula:
C12H17NO2•(C2H4O)n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Benzonatate, a synthetic butylamino-benzoate derivative, acts as a peripherally acting antitussive. It functions as a reversible blocker of voltage-gated sodium channels, specifically inhibiting Nav1.7 currents in a concentration- and voltage-dependent manner. Furthermore, it suppresses action potential firing in catecholamine A differentiated (CAD) cells. Structurally resembling polyglycol ester local anesthetics like procaine and tetracaine, benzonatate is classified as a butylamine. Upon hydrolysis by plasma butyrylcholinesterase (BChE), it yields the metabolite 4-(butylamino)benzoic acid (BABA) as well as polyethylene glycol monomethyl esters.
Benzonatate (CAS 104-31-4) References
- Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough. | Dicpinigaitis, PV., et al. 2009. Respir Med. 103: 902-6. PMID: 19121573
- Nebulized lidocaine in the treatment of intractable cough. | Truesdale, K. and Jurdi, A. 2013. Am J Hosp Palliat Care. 30: 587-9. PMID: 22964341
- Benzonatate toxicity in a teenager resulting in coma, seizures, and severe metabolic acidosis. | Thimann, DA., et al. 2012. J Pediatr Pharmacol Ther. 17: 270-3. PMID: 23258970
- Genotoxicity assessment of the novel antitussive agent Benzonatate and its major metabolite. | Teo, S., et al. 2018. Mutat Res Genet Toxicol Environ Mutagen. 829-830: 19-25. PMID: 29704989
- The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies. | Teo, S., et al. 2018. Toxicol Pathol. 46: 683-692. PMID: 30033829
- Determination of benzonatate and its metabolite in human plasma by HPLC-MS/MS: A preliminary pharmacokinetic study in healthy Chinese volunteers after oral administration of benzonatate soft capsule. | Man, J., et al. 2019. J Pharm Biomed Anal. 173: 134-143. PMID: 31129533
- Impact of a drug safety communication on the severity of benzonatate exposures reported to poison centers. | Leonard, JB., et al. 2021. Pharmacoepidemiol Drug Saf. 30: 45-52. PMID: 32964590
- Arrhythmogenic Antitussive: A Case of Pediatric Benzonatate Overdose With Torsades de Pointes, Cardiac Arrest, and Complete Recovery Without Neurologic Deficits. | Billington, M., et al. 2020. J Pediatr Pharmacol Ther. 25: 642-646. PMID: 33041720
- A description of the clinical course of severe benzonatate poisonings reported in the literature and to NPDS: A systematic review supplemented with NPDS cases. | Minhaj, FS. and Leonard, JB. 2021. Hum Exp Toxicol. 40: S39-S48. PMID: 34219543
- Benzonatate Overdose Presenting as Cardiac Arrest with Rapidly Narrowing QRS Interval. | Stephens, RJ., et al. 2022. J Med Toxicol. 18: 344-349. PMID: 35790679
- Benzonatate Exposure Trends and Adverse Events. | Kim, I., et al. 2022. Pediatrics. 150: PMID: 36377394
- Benzonatate Safety and Effectiveness: A Systematic Review of the Literature. | Costantino, RC., et al. 2023. Ann Pharmacother. 10600280221135750. PMID: 36688284
- Benzonatate as a local anesthetic. | McGuire, A., et al. 2023. PLoS One. 18: e0284401. PMID: 37043508
- Benzonatate overdose associated with seizures and arrhythmias. | Crouch, BI., et al. 1998. J Toxicol Clin Toxicol. 36: 713-8. PMID: 9865240
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzonatate, 10 mg | sc-207327 | 10 mg | $357.00 |