BDP1 Antibody (A-3): sc-166745
- BDP1 Antibody (A-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 435-454 near the C-terminus of BDP1 of human origin
- recommended for detection of BDP1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including porcine; may cross-react with PTP-PEST
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for BDP1 Antibody (A-3) for WB and IHC(P) applications. These reagents are now offered in bundles with BDP1 Antibody (A-3) (see ordering information below).
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BDP1 Antibody (A-3) is a mouse monoclonal IgG1 antibody that detects BDP1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BDP1, or brain-derived phosphatase 1, is a crucial member of the PEST protein tyrosine phosphatase family, playing a significant role in the regulation of protein tyrosine phosphorylation, which is essential for numerous cellular processes such as growth, migration, and differentiation. BDP1 expression extends beyond the brain, as BDP1 is also found in the colon and various tumor-derived cell lines, indicating potential involvement in cancer biology. Notably, BDP1 has been shown to selectively dephosphorylate autophosphorylated tyrosine kinases, including src and epidermal growth factor receptor (EGFR), which are often overexpressed in tumor tissues. This selective action highlights BDP1′s potential as a therapeutic target and relevance in understanding tumorigenesis, making anti-BDP1 antibody (A-3) an invaluable tool for researchers investigating the dynamics of protein phosphorylation in both normal and pathological states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BDP1 Antibody (A-3) References:
- Essential roles of Bdp1, a subunit of RNA polymerase III initiation factor TFIIIB, in transcription and tRNA processing. | Ishiguro, A., et al. 2002. Mol Cell Biol. 22: 3264-75. PMID: 11971960
- The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. | Schoenen, F. and Wirth, B. 2006. Biol Chem. 387: 277-84. PMID: 16542149
- A Region of Bdp1 Necessary for Transcription Initiation That Is Located within the RNA Polymerase III Active Site Cleft. | Hu, HL., et al. 2015. Mol Cell Biol. 35: 2831-40. PMID: 26055328
- Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation. | Gouge, J., et al. 2017. Nat Commun. 8: 130. PMID: 28743884
- Bdp1 interacts with SNAPc bound to a U6, but not U1, snRNA gene promoter element to establish a stable protein-DNA complex. | Verma, N., et al. 2018. FEBS Lett. 592: 2489-2498. PMID: 29932462
- Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers. | Son, HJ., et al. 2020. Pathol Res Pract. 216: 153107. PMID: 32853945
- BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. | Li, X., et al. 2021. Diagnostics (Basel). 11: PMID: 34943600
- Comment on Li et al. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics 2021, 11, 2364. | Schramm, L. 2022. Diagnostics (Basel). 12: PMID: 35328161
- BDP1 Alterations Correlate with Clinical Outcomes in Breast Cancer. | Cabarcas-Petroski, S. and Schramm, L. 2022. Cancers (Basel). 14: PMID: 35406430
- BDP1 as a biomarker in serous ovarian cancer. | Cabarcas-Petroski, S., et al. 2023. Cancer Med. 12: 6401-6418. PMID: 36305848
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BDP1 Antibody (A-3) | sc-166745 | 200 µg/ml | $322.00 | |||
BDP1 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-540150 | 200 µg Ab; 10 µg BP | $361.00 | |||
BDP1 Antibody (A-3): m-IgG1 BP-HRP Bundle | sc-541936 | 200 µg Ab; 20 µg BP | $361.00 | |||
BDP1 (A-3) Neutralizing Peptide | sc-166745 P | 100 µg/0.5 ml | $69.00 |