BCoR Antibody (C-10): sc-514576
- BCoR Antibody (C-10) is a mouse monoclonal IgG1 κ BCoR antibody, cited in 35 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of BCoR of human origin
- BCoR Antibody (C-10) is recommended for detection of BCoR of human origin by WB, IP, IF and ELISA
- Anti-BCoR Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BCoR Antibody (C-10) for WB applications. These reagents are now offered in bundles with BCoR Antibody (C-10) (see ordering information below).
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BCoR Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects BCoR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BCoR antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BCoR, or BCL-6 corepressor, is a crucial 1,755 amino acid protein that plays a significant role in transcriptional repression by associating with histone deacetylases (HDACs) to inhibit the activity of Bcl-6, a transcriptional repressor involved in regulating apoptosis and immune responses. BCoR is predominantly localized in the nucleus, where BCoR interacts with other proteins through three ankyrin repeat domains, facilitating function in gene regulation. Mutations in the BCoR gene can lead to microphthalmia with associated anomalies 2, a condition characterized by a range of developmental issues, including renal aplasia and mental retardation. BCoR is expressed ubiquitously across various tissues, and four isoforms, produced through alternative splicing, contribute to diverse regulatory roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BCoR Antibody (C-10) References:
- BCoR, a novel corepressor involved in BCL-6 repression. | Huynh, KD., et al. 2000. Genes Dev. 14: 1810-23. PMID: 10898795
- Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. | Ng, D., et al. 2004. Nat Genet. 36: 411-6. PMID: 15004558
- Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. | Gearhart, MD., et al. 2006. Mol Cell Biol. 26: 6880-9. PMID: 16943429
- A two base pair deletion in the PQBP1 gene is associated with microphthalmia, microcephaly, and mental retardation. | Martínez-Garay, I., et al. 2007. Eur J Hum Genet. 15: 29-34. PMID: 17033686
- Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. | Sánchez, C., et al. 2007. Mol Cell Proteomics. 6: 820-34. PMID: 17296600
- Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. | Ghetu, AF., et al. 2008. Mol Cell. 29: 384-91. PMID: 18280243
- Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development. | Wamstad, JA., et al. 2008. PLoS One. 3: e2814. PMID: 18795143
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BCoR Antibody (C-10) | sc-514576 | 200 µg/ml | $322.00 | |||
BCoR Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-531167 | 200 µg Ab; 10 µg BP | $361.00 | |||
BCoR Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-524777 | 200 µg Ab, 40 µg BP | $361.00 | |||
BCoR Antibody (C-10) AC | sc-514576 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BCoR Antibody (C-10) HRP | sc-514576 HRP | 200 µg/ml | $322.00 | |||
BCoR Antibody (C-10) FITC | sc-514576 FITC | 200 µg/ml | $336.00 | |||
BCoR Antibody (C-10) PE | sc-514576 PE | 200 µg/ml | $349.00 | |||
BCoR Antibody (C-10) Alexa Fluor® 488 | sc-514576 AF488 | 200 µg/ml | $364.00 | |||
BCoR Antibody (C-10) Alexa Fluor® 546 | sc-514576 AF546 | 200 µg/ml | $364.00 | |||
BCoR Antibody (C-10) Alexa Fluor® 594 | sc-514576 AF594 | 200 µg/ml | $364.00 | |||
BCoR Antibody (C-10) Alexa Fluor® 647 | sc-514576 AF647 | 200 µg/ml | $364.00 | |||
BCoR Antibody (C-10) Alexa Fluor® 680 | sc-514576 AF680 | 200 µg/ml | $364.00 | |||
BCoR Antibody (C-10) Alexa Fluor® 790 | sc-514576 AF790 | 200 µg/ml | $364.00 |