Bcl-2 Antibody (YTH10C4): sc-81002
- Bcl-2 Antibody (YTH10C4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to amino acids 61-76 of Bcl-2 of human origin
- recommended for detection of Bcl-2 of mouse and rat origin by WB, IP and IF
- See Bcl-2 (C-2): sc-7382 for Bcl-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Bcl-2 Antibody (YTH10C4) for WB applications. These reagents are now offered in bundles with Bcl-2 Antibody (YTH10C4) (see ordering information below).
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Bcl-2 Antibody (YTH10C4) is a mouse monoclonal IgG1 antibody that detects Bcl-2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Bcl-2 is a crucial anti-apoptotic protein that plays a significant role in regulating apoptosis, which is vital for maintaining tissue homeostasis and protecting against diseases, including cancer. Located primarily in the outer mitochondrial membrane, Bcl-2′s strategic positioning allows for effective inhibition of pro-apoptotic factor release, thereby preventing cell death. This localization enables Bcl-2 to interact with other members of the Bcl-2 family, such as Bax and Bak, which are key players in the apoptotic pathway. By stabilizing the mitochondrial membrane, Bcl-2 not only promotes cell survival but also contributes to the overall balance between cell proliferation and death, a process that, when disrupted, can lead to tumorigenesis. Anti-Bcl-2 antibody (YTH10C4) is an invaluable tool for researchers studying the mechanisms of apoptosis and the implications of Bcl-2 in various diseases, particularly in understanding how dysregulation can lead to cancer progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bcl-2 Antibody (YTH10C4) References:
- BCL-2 stimulates Apoptin-induced apoptosis. | Danen-Van Oorschot, AA., et al. 1999. Adv Exp Med Biol. 457: 245-9. PMID: 10500799
- Bcl-2 regulation of mitochondrial energetics. | Murphy, E., et al. 2005. Trends Cardiovasc Med. 15: 283-90. PMID: 16297765
- The p53-Bcl-2 connection. | Hemann, MT. and Lowe, SW. 2006. Cell Death Differ. 13: 1256-9. PMID: 16710363
- Bcl-2 inhibitors: emerging drugs in cancer therapy. | Bodur, C. and Basaga, H. 2012. Curr Med Chem. 19: 1804-20. PMID: 22414090
- Targeting the Bcl-2 family for cancer therapy. | Thomas, S., et al. 2013. Expert Opin Ther Targets. 17: 61-75. PMID: 23173842
- Bcl-2 inhibitors reduce steroid-insensitive airway inflammation. | Tian, BP., et al. 2017. J Allergy Clin Immunol. 140: 418-430. PMID: 28043871
- Noncanonical Cell Fate Regulation by Bcl-2 Proteins. | Chong, SJF., et al. 2020. Trends Cell Biol. 30: 537-555. PMID: 32307222
- Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction. | Dong, X., et al. 2022. ACS Med Chem Lett. 13: 1510-1516. PMID: 36105331
- Prime, shock and kill: BCL-2 inhibition for HIV cure. | Chandrasekar, AP. and Badley, AD. 2022. Front Immunol. 13: 1033609. PMID: 36341439
- Bcl-2 and Bcl-2-related proteins in apoptosis regulation. | Boise, LH., et al. 1995. Curr Top Microbiol Immunol. 200: 107-21. PMID: 7634826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-2 Antibody (YTH10C4) | sc-81002 | 200 µg/ml | $322.00 | |||
Bcl-2 Antibody (YTH10C4): m-IgG Fc BP-HRP Bundle | sc-539584 | 200 µg Ab; 10 µg BP | $361.00 | |||
Bcl-2 Antibody (YTH10C4): m-IgG1 BP-HRP Bundle | sc-541575 | 200 µg Ab; 20 µg BP | $361.00 |