Aspartoacylase-3 Antibody (A-9): sc-374559

Aspartoacylase-3 Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Aspartoacylase-3 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Aspartoacylase-3, also known as aminoacylase-3, is a 319 amino acid protein primarily located in the proximal tubules of the kidney, where Aspartoacylase-3 plays a crucial role in the deacetylation of mercapturic acids, thereby contributing to the detoxification processes in renal function. The localization of Aspartoacylase-3 to the cytoplasm of S2 and S3 proximal tubules, as well as the apical domain of S1 proximal tubules, highlights Aspartoacylase-3′s involvement in renal metabolism and potential implications in kidney-related disorders. Additionally, Aspartoacylase-3 is expressed at lower levels in other tissues such as the stomach, testis, heart, brain, lung, and liver, and may also function as a core binding protein for the Hepatitis C virus, indicating Aspartoacylase-3′s relevance in viral pathogenesis. The gene encoding Aspartoacylase-3 is situated on human chromosome 11, a region associated with several genetic disorders, underscoring Aspartoacylase-3′s importance in both health and disease. Anti-Aspartoacylase-3 antibody (A-9) is an essential tool for researchers investigating the functional roles and pathological implications of Aspartoacylase-3 in various biological contexts.

The preferred Aspartoacylase-3 antibody is Aspartoacylase-3 Antibody (A-5): sc-393862.