Aclacinomycin A CAS: 57576-44-0
MF: C42H53NO15
MW: 811.87

Aclacinomycin A (CAS 57576-44-0)

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Aclacinomycin A is rated 5.0 out of 5 by 1.
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Nombres Alternativos: Aclacinomycin A is also known as Aclarubicin.
Solicitud: Aclacinomycin A is an anticancer anthracycline drug and non-peptidic inhibitor of CTRL and calpain.
Número de CAS: 57576-44-0
Pureza: ≥95%
Peso Molecular: 811.87
Fórmula Molecular: C42H53NO15
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Aclacinomycin A was originally identified as an anti-tumor drug produced by Streptomyces galilaeus. Aclacinomycin A is the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A has no effect on cathepsin B, it stimulates trypsin activity but inhibits the activity of both chymotrypsin and calpain. The family of aclacinomycins (of which Aclarubicin is a member) consist of highly colored compounds of which 13 yellow and 7 red-colored components have been identified. Aclarubicin has been observed to act by forming a stable complex with DNA and thus interferes with the synthesis of nucleic acids. It possesses immunosuppressant, antibacterial and antiviral properties. The aglycone portion of Aclarubicin A is known as aklavinone.


References

1. T. Isoe et al. Biochim. Biophys. Acta 1992 1117 131
2. M.E. Figueirodo-Pereira et al. J. Biol. Chem. 1996 271 16455
3. Jensen PB, Jensen PS, Demant EJ, et al. (October 1991). "Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II". Cancer Res. 51 (19): 5093–9. PMID1655244
4. Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, Nieuwland M, Ovaa H, Rottenberg S, van Tellingen O, Janssen J, Huijgens P, Zwart W, Neefjes J (2013). "Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin". Nature Communications. 4: 1908. doi:10.1038/ncomms2921. PMC3674280. PMID23715267

Apariencia :
Powder
Estado de Materia :
Solid
Solubilidad :
Soluble in water (Partly miscible), DMSO (25 mg/ml), DMF (25 mg/ml), methanol, chloroform, and ethyl acetate.
ALMACENAMIENTO :
Store at -20° C
Punto de ebullición :
~897.7° C at 760 mmHg (Predicted)
Densidad :
~1.4 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.63
IC50 :
Matrix metalloproteinase-2: IC50 = 9.9 µM (Homo sapiens); Clostridium histolyticum collagenase: IC50 = 9.9 µM; [3H]TdR incorporation in Yoshida sarcoma tumor cells: IC50 = 0.02 µM (rat)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
QI9279300
PubChem CID :
451415
Número MDL :
MFCD00866250
Número EC :
260-824-3

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Citaciones 1 a 4 de un total de 4

PMID: # 26320659  Hasan, M. et al. 2015. Immunity. 43: 463-74.

PMID: # 8663210  Figueiredo-Pereira, ME. et al. 1996. J. Biol. Chem. 271: 16455-16459.

PMID: # 32554494  Proc. Natl. Acad. Sci. U.S.A.

PMID: # 32961780  Pharmaceuticals (Basel).

Citaciones 1 a 4 de un total de 4
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