Molecular structure of A-803467, CAS Number: 944261-79-4
A-803467 (CAS 944261-79-4)
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Application:
A-803467 is a sodium channel protein inhibitor
CAS Number:
944261-79-4
Purity:
98%
Molecular Weight:
357.8
Molecular Formula:
C19H16ClNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A-803467 is a potent and selective sodium channel protein inhibitor of the TTX-resistant voltage-gated sodium channel Na+ CP type X alpha (Nav 1.8) which is preferentially expressed on sensory neurons. A-803467 is a powerful inhibitor that selectively targets the NaV1.8 channel, effectively blocking its activity with an IC50 value of 8 nM. This compound specifically hinders tetrodotoxin-resistant currents, displaying remarkable selectivity of over 100-fold when compared to human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 channels.
A-803467 (CAS 944261-79-4) References
- A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. | Jarvis, MF., et al. 2007. Proc Natl Acad Sci U S A. 104: 8520-5. PMID: 17483457
- A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. | McGaraughty, S., et al. 2008. J Pharmacol Exp Ther. 324: 1204-11. PMID: 18089840
- Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. | Joshi, SK., et al. 2009. J Pain. 10: 306-15. PMID: 19070548
- Functional and pharmacological properties of human and rat NaV1.8 channels. | Browne, LE., et al. 2009. Neuropharmacology. 56: 905-14. PMID: 19371587
- The effects of A-803467 on cardiac Nav1.5 channels. | Han, Z., et al. 2015. Eur J Pharmacol. 754: 52-60. PMID: 25701724
- A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. | Anreddy, N., et al. 2015. Oncotarget. 6: 39276-91. PMID: 26515463
- Dynamic weight bearing as a non-reflexive method for the measurement of abdominal pain in mice. | Laux-Biehlmann, A., et al. 2016. Eur J Pain. 20: 742-52. PMID: 26684879
- Neuronal Nav1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention. | Chen, X., et al. 2016. J Am Heart Assoc. 5: PMID: 27806967
- Blocking the Nav1.8 channel in the left stellate ganglion suppresses ventricular arrhythmia induced by acute ischemia in a canine model. | Yu, L., et al. 2017. Sci Rep. 7: 534. PMID: 28373696
- The voltage-gated sodium channel NaV1.8 blocker A-803467 inhibits cough in the guinea pig. | Brozmanova, M., et al. 2019. Respir Physiol Neurobiol. 270: 103267. PMID: 31398537
- Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes. | Casini, S., et al. 2019. Cardiovasc Drugs Ther. 33: 649-660. PMID: 31916131
- Blockade of NaV1.8 Increases the Susceptibility to Ventricular Arrhythmias During Acute Myocardial Infarction. | Qi, B., et al. 2021. Front Cardiovasc Med. 8: 708279. PMID: 34409080
- Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8. | Huang, X., et al. 2022. Proc Natl Acad Sci U S A. 119: e2208211119. PMID: 35858452
Inhibitor of:
AQP4, Na+ CP type X alpha, Na+ CP type Xα, NaS-1, Neuron navigator 1, Olfr551, OR2V1, P2X1, PHD (peptidyl-proline 4-dioxygenase), S-100A5, and smoothelin.Activator of:
sodium channel type II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-803467, 10 mg | sc-201068 | 10 mg | $89.00 | |||
A-803467, 25 mg | sc-201068B | 25 mg | $188.00 | |||
A-803467, 50 mg | sc-201068A | 50 mg | $349.00 |