9-Methylguanine (CAS 5502-78-3)
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In recent years, there has been significant research on 9-Methylguanine (9-MG), a guanine derivative with promising applications in various scientific fields. It is a naturally occurring nucleoside found in mammalian cells′ nucleic acid, known for its biochemical and physiological effects. The versatile nature of 9-Methylguanine has led to its utilization in diverse scientific research areas such as cancer research, gene editing, and drug delivery. It has been particularly valuable in investigating DNA damage resulting from chemotherapy and radiation, as well as studying gene mutations caused by environmental toxins. Although the mechanism of action of 9-Methylguanine is not entirely understood, it is believed to involve the formation of a covalent bond between the guanine base and the methyl group present on the 9-Methylguanine molecule. This covalent bond is thought to induce structural changes in DNA, ultimately affecting gene expression and cellular function.
9-Methylguanine (CAS 5502-78-3) References
- Binding of 9-methylguanine to [cis-Ru(2,2'-bpy)2]2+: First X-ray structure of a cis-bis purine complex of ruthenium. | Zobi, F., et al. 2004. Inorg Chem. 43: 2771-2. PMID: 15106961
- Interguanine hydrogen-bonding patterns in adducts with water and Zn-purine complexes (purine is 9-methyladenine and 9-methylguanine). Unexpected preference of Zn(II) for adenine-N7 over guanine-N7. | Amo-Ochoa, P., et al. 2007. J Biol Inorg Chem. 12: 543-55. PMID: 17310379
- Role of Quantum Vibrations on the Structural, Electronic, and Optical Properties of 9-Methylguanine. | Law, YK. and Hassanali, AA. 2015. J Phys Chem A. 119: 10816-27. PMID: 26444383
- How protonation and deprotonation of 9-methylguanine alter its singlet O2 addition path: about the initial stage of guanine nucleoside oxidation. | Lu, W., et al. 2016. Phys Chem Chem Phys. 18: 15223-34. PMID: 27211529
- Alternated Branching Ratios by Anomaly in Collision-Induced Dissociation of Proton-Bound Hoogsteen Base Pairs of 1-Methylcytosine with 1-Methylguanine and 9-Methylguanine. | Park, JJ. and Han, SY. 2019. J Am Soc Mass Spectrom. 30: 846-854. PMID: 30911905
- UV-Vis Action Spectroscopy of Guanine, 9-Methylguanine, and Guanosine Cation Radicals in the Gas Phase. | Dang, A., et al. 2019. J Phys Chem A. 123: 3272-3284. PMID: 30912657
- UV-promoted radical formation, and near-IR-induced and spontaneous conformational isomerization in monomeric 9-methylguanine isolated in low-temperature Ar matrices. | Nowak, MJ., et al. 2019. Phys Chem Chem Phys. 21: 22857-22868. PMID: 31599896
- Dynamics and Multiconfiguration Potential Energy Surface for the Singlet O2 Reactions with Radical Cations of Guanine, 9-Methylguanine, 2'-Deoxyguanosine, and Guanosine. | Sun, Y., et al. 2021. J Phys Chem A. 125: 1564-1576. PMID: 33571415
- Synthesis, characterization, interactions with 9-MeG and cytotoxic activity of heterobimetallic RuII-PtII complexes bridged with 2, 2'-bipyrimidine. | Tsolis, T., et al. 2021. J Inorg Biochem. 219: 111435. PMID: 33819801
- Reaction mechanism and dynamics for C8-hydroxylation of 9-methylguanine radical cation by water molecules. | Zhou, W. and Liu, J. 2021. Phys Chem Chem Phys. 23: 24464-24477. PMID: 34698322
- Collision-induced dissociation of homodimeric and heterodimeric radical cations of 9-methylguanine and 9-methyl-8-oxoguanine: correlation between intra-base pair proton transfer originating from the N1-H at a Watson-Crick edge and non-statistical dissociation. | Moe, MM., et al. 2022. Phys Chem Chem Phys. 24: 9263-9276. PMID: 35403654
- Singlet O2 Oxidation of the Radical Cation versus the Dehydrogenated Neutral Radical of 9-Methylguanine in a Watson-Crick Base Pair. Consequences of Structural Context. | Moe, MM., et al. 2022. J Phys Chem B. 126: 5458-5472. PMID: 35849846
- Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity. | Liu, X., et al. 2022. Chem Biodivers. 19: e202200695. PMID: 36026613
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Methylguanine, 250 mg | sc-233736 | 250 mg | $321.00 |