5(S),6(R)-Lipoxin A4-d5 (CAS 1622429-53-1)
Alternate Names:
(5S,6R,7E,9E,11Z,13E,15S)-19,19,20,20,20-pentadeuterio-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
CAS Number:
1622429-53-1
Molecular Weight:
357.5
Molecular Formula:
C20H27D5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5(S),6(R)-Lipoxin A4-d5 (5(S),6(R)-LXA4-d5) contains five deuterium atoms at the 19, 19′, 20, 20, and 20 positions. It is used as an internal standard for quantification of 5(S),6(R)-LXA4 by GC- or LC-mass spectrometry (MS). 5(S),6(R)-Lipoxin A4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes(1). 5(S),6(R)-Lipoxin A4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM(2). 5(S),6(R)-Lipoxin A4 is associated with several other biological functions including leukocyte activation, natural killer cell, chemotaxis effects, inhibition, and monocyte migration and adhesion(2,3,4).
5(S),6(R)-Lipoxin A4-d5 (CAS 1622429-53-1) References
1 Serhan, C.N., Nicolaou, K.C., Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. J Biol Chem 261 16340-16345 (1986). 2 Serhan, C.N., Hamberg, M., Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci USA 81 5335-5339 (1984). 3 Ramstedt, U., Serhan, C.N., Nicolaou, K.C., et al. Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: Studies on stereospecificity of inhibition and mode of action. J Immunol 138 266-270 (1987). 4 Maddox, J.F., Serhan, C.N. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction. J Exp Med 183 137-146 (1996)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5(S),6(R)-Lipoxin A4-d5, 10 µg | sc-221077 | 10 µg | $205.00 | |||
5(S),6(R)-Lipoxin A4-d5, 25 µg | sc-221077A | 25 µg | $490.00 |