Date published: 2026-6-10

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4-Hydroxy Estrone (CAS 3131-23-5)

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Application:
4-Hydroxy Estrone is An Estradiol metabolite
CAS Number:
3131-23-5
Molecular Weight:
286.37
Molecular Formula:
C18H22O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Hydroxy Estrone is an Estradiol metabolite. It serves as a tool to investigate the effects of estradiol and its metabolites on fundamental biological phenomena like cell proliferation and apoptosis. Moreover, it aids in the study of estradiol′s impact on gene expression and the regulation of hormone receptors.


4-Hydroxy Estrone (CAS 3131-23-5) References

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  2. In vitro short-term test evaluation of catecholestrogens genotoxicity.  |  Rossi, D., et al. 2007. J Steroid Biochem Mol Biol. 105: 98-105. PMID: 17590328
  3. Contribution of alpha2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells.  |  Chiesa, IJ., et al. 2008. J Steroid Biochem Mol Biol. 110: 170-5. PMID: 18486470
  4. U-statistics-based tests for multiple genes in genetic association studies.  |  Wei, Z., et al. 2008. Ann Hum Genet. 72: 821-33. PMID: 18691161
  5. Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells.  |  Pavan, B., et al. 2011. Life Sci. 88: 551-8. PMID: 21277863
  6. Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells.  |  Kamel, M., et al. 2012. J Cancer. 3: 310-21. PMID: 22866165
  7. Bioanalytical LC-MS Method for the Quantification of Plasma Androgens and Androgen Glucuronides in Breast Cancer.  |  Kalogera, E., et al. 2016. J Chromatogr Sci. 54: 583-92. PMID: 26762957
  8. Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities.  |  Liu, YQ., et al. 2016. Sci Rep. 6: 23763. PMID: 27025983
  9. Estrogen metabolism in menopausal hormone users in the women's health initiative observational study: Does it differ between estrogen plus progestin and estrogen alone?  |  Falk, RT., et al. 2019. Int J Cancer. 144: 730-740. PMID: 30183089
  10. Tissue steroid levels in response to reduced testicular estrogen synthesis in the male pig, Sus scrofa.  |  Kucera, H., et al. 2019. PLoS One. 14: e0215390. PMID: 30986232
  11. Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry.  |  Denver, N., et al. 2019. Data Brief. 23: 103740. PMID: 31372406
  12. Estrone degrading enzymes of Spirulina CPCC-695 and synthesis of bioplastic precursor as a by-product.  |  Sami, N., et al. 2020. Biotechnol Rep (Amst). 26: e00464. PMID: 32420052
  13. Steroid sulfation by expressed human cytosolic sulfotransferases.  |  Falany, CN., et al. 1994. J Steroid Biochem Mol Biol. 48: 369-75. PMID: 8142314
  14. Covalent binding of catechol estrogens to glutathione catalyzed by horseradish peroxidase, lactoperoxidase, or rat liver microsomes.  |  Cao, K., et al. 1998. Chem Res Toxicol. 11: 917-24. PMID: 9705754

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Hydroxy Estrone, 1 mg

sc-206889
1 mg
$252.00