Date published: 2026-4-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-Aminopiperidine-2,6-dione hydrochloride (CAS 24666-56-6)

0.0(0)
Write a reviewAsk a question

Alternate Names:
3-Amino-2,6-piperidinedione hydrochloride
CAS Number:
24666-56-6
Molecular Weight:
164.59
Molecular Formula:
C5H9ClN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-Aminopiperidine-2,6-dione hydrochloride is a chemical compound characterized by its incorporation of a piperidine ring—a six-membered heterocycle containing one nitrogen atom—modified with amino and dione functionalities at specific positions, and stabilized as a hydrochloride salt. This structure confers it distinct chemical and physical properties, making it a valuable reagent in organic and medicinal chemistry research, particularly in the synthesis and modification of peptides and peptidomimetics. The presence of the amino group offers a site for nucleophilic attack, enabling the formation of bonds with electrophilic centers, while the dione moiety can participate in condensation reactions or act as a chelating agent. The hydrochloride salt form improves its solubility in polar solvents, facilitating its handling and application in aqueous reaction conditions.


3-Aminopiperidine-2,6-dione hydrochloride (CAS 24666-56-6) References

  1. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.  |  Zhou, B., et al. 2018. J Med Chem. 61: 462-481. PMID: 28339196
  2. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.  |  Winter, GE., et al. 2017. Mol Cell. 67: 5-18.e19. PMID: 28673542
  3. YY1 Is a Structural Regulator of Enhancer-Promoter Loops.  |  Weintraub, AS., et al. 2017. Cell. 171: 1573-1588.e28. PMID: 29224777
  4. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).  |  Chessum, NEA., et al. 2018. J Med Chem. 61: 918-933. PMID: 29240418
  5. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.  |  Brand, M., et al. 2019. Cell Chem Biol. 26: 300-306.e9. PMID: 30595531
  6. Selective degradation of CDK6 by a palbociclib based PROTAC.  |  Rana, S., et al. 2019. Bioorg Med Chem Lett. 29: 1375-1379. PMID: 30935795
  7. On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.  |  Heim, C., et al. 2021. Biochem Biophys Res Commun. 534: 67-72. PMID: 33310190
  8. Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91.  |  Hanafi, M., et al. 2021. J Med Chem. 64: 1626-1648. PMID: 33506674
  9. A PROTAC targets splicing factor 3B1.  |  Gama-Brambila, RA., et al. 2021. Cell Chem Biol. 28: 1616-1627.e8. PMID: 34048672
  10. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points.  |  Bricelj, A., et al. 2021. Front Chem. 9: 707317. PMID: 34291038
  11. Design, synthesis, and biological evaluation of a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon modulators.  |  Liu, Y., et al. 2022. J Enzyme Inhib Med Chem. 37: 1715-1723. PMID: 35698881
  12. Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.  |  Takwale, AD., et al. 2022. Bioorg Chem. 127: 105923. PMID: 35717803
  13. Identification and structural basis of C-terminal cyclic imides as natural degrons for cereblon.  |  Heim, C., et al. 2022. Biochem Biophys Res Commun. 637: 66-72. PMID: 36375252
  14. Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents.  |  Kotb, AR., et al. 2022. RSC Adv. 12: 33525-33539. PMID: 36505721
  15. Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.  |  Bonazzi, S., et al. 2023. Cell Chem Biol. 30: 235-247.e12. PMID: 36863346

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Aminopiperidine-2,6-dione hydrochloride, 1 g

sc-482281
1 g
$45.00

3-Aminopiperidine-2,6-dione hydrochloride, 5 g

sc-482281A
5 g
$89.00

3-Aminopiperidine-2,6-dione hydrochloride, 25 g

sc-482281B
25 g
$141.00

3-Aminopiperidine-2,6-dione hydrochloride, 100 g

sc-482281C
100 g
$401.00