TMEM59 Activadores
TMEM59," or "Transmembrane Protein 59," is a gene that encodes a protein belonging to the family of transmembrane proteins. As suggested by its name, TMEM59 is characterized by its location within the cellular membrane, indicating a role in cellular processes involving membrane dynamics.TMEM59 is involved in the regulation of endosomal trafficking, a critical process in the cellular transport and sorting of membrane-bound proteins and lipids. Endosomal trafficking is essential for various cellular functions, including signaling, nutrient uptake, and membrane protein recycling or degradation. TMEM59 contributes to the proper functioning of this system by influencing the movement and sorting of endosomal vesicles.
One of the key roles of TMEM59 is in the modulation of the Golgi apparatus, a central organelle in protein and lipid processing and trafficking. TMEM59 has been implicated in Golgi-to-endosome transport, influencing the sorting and delivery of proteins to their appropriate cellular destinations.Research has also highlighted the involvement of TMEM59 in neurodegenerative diseases, particularly in the context of Alzheimer's disease. TMEM59 may affect the processing and trafficking of amyloid precursor protein (APP), a key protein in the pathogenesis of Alzheimer's disease. Alterations in APP processing can lead to the accumulation of amyloid-beta, a hallmark of Alzheimer's pathology.Moreover, TMEM59's role in membrane trafficking and cell signaling pathways suggests its broader relevance in various physiological processes and potentially in other disease mechanisms.
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| Nombre del producto | NÚMERO DE CAS # | Número de catálogo | Cantidad | Precio | MENCIONES | Clasificación |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Regulador de la expresión génica, el ácido retinoico puede influir en varias vías de señalización, lo que podría afectar al TMEM59. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Un inhibidor de la bomba de protones V-ATPasa, que afecta a la acidificación lisosomal e influye potencialmente en el papel de TMEM59 en la clasificación lisosomal. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Conocida por afectar a la función lisosomal, la cloroquina puede afectar indirectamente a la actividad TMEM59 relacionada con la clasificación lisosomal. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Un inhibidor de GSK-3, que afecta a la señalización Wnt y puede afectar a la función TMEM59. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $62.00 | 8 | ||
Un agente lisosomotrópico que puede elevar el pH lisosomal, influyendo potencialmente en el papel de TMEM59 en la función lisosomal. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Un inhibidor de mTOR, que influye en la autofagia y la función lisosomal, con un impacto potencial en TMEM59. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Un inhibidor de la glicosilación ligada a N, que afecta al tráfico de proteínas y potencialmente a la función de TMEM59. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Agente despolimerizador de microtúbulos, que afecta al transporte intracelular, influyendo potencialmente en la TMEM59. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
El IWP-2, un inhibidor de la producción de Wnt, puede afectar indirectamente a la función de TMEM59 en las vías de señalización Wnt. | ||||||