Date published: 2026-1-11

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PRB1-3 Inhibidores

PRB1-3 inhibitors are a class of chemical compounds designed to target and inhibit the function of PRB1-3, which refers to members of the PRB (Proline-Rich Protein B) family, specifically PRB1, PRB2, and PRB3. These proteins are primarily found in salivary glands, where they play key roles in the secretion and function of saliva. PRB1-3 proteins belong to the proline-rich protein family, which is involved in various biological processes such as the maintenance of oral health, lubrication, and the formation of the protective film in the oral cavity. These proteins are known to interact with other salivary components and help modulate the mineral balance in the oral cavity, contributing to tooth enamel maintenance and protection against environmental factors. Inhibition of PRB1-3 allows researchers to study the molecular mechanisms underlying these functions, providing a better understanding of how these proteins contribute to oral physiology.

In research settings, PRB1-3 inhibitors are used to investigate the regulatory roles of these proteins in oral and salivary gland function. By blocking the activity of PRB1-3 proteins, scientists can explore how these inhibitors affect processes such as saliva composition, mineral homeostasis, and the protective functions that saliva provides. This inhibition allows for the analysis of how PRB1-3 proteins contribute to the overall maintenance of the oral environment, including their potential role in interactions with other salivary proteins and enzymes. Additionally, PRB1-3 inhibitors provide insight into the downstream effects on oral health, offering valuable data on how disruptions in salivary protein function can lead to imbalances in oral hygiene and physiology. Through these studies, the use of PRB1-3 inhibitors enhances our understanding of the complex molecular systems that regulate the function of saliva and its crucial role in maintaining oral health and integrity.

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Nombre del productoNÚMERO DE CAS #Número de catálogoCantidadPrecioMENCIONESClasificación

Benzamidine

618-39-3sc-233933
10 g
$292.00
1
(0)

La benzamidina es un inhibidor competitivo de serina proteasas como la tripsina, de la que forma parte la PRB1. Se une al sitio activo de la PRB1, impidiendo el acceso del sustrato e inhibiendo así su actividad proteasa.

Phenylmethylsulfonyl Fluoride

329-98-6sc-3597
sc-3597A
1 g
100 g
$50.00
$697.00
92
(1)

El PMSF inhibe irreversiblemente las serina proteasas al sulfonilar el grupo hidroxilo de la serina del sitio activo de la PRB1, que es esencial para su actividad proteolítica.

Aprotinin

9087-70-1sc-3595
sc-3595A
sc-3595B
10 mg
100 mg
1 g
$112.00
$408.00
$3000.00
51
(2)

La aprotinina es una pequeña proteína que actúa como inhibidor competitivo uniéndose fuertemente a los sitios activos de las serina proteasas, incluida la PRB1, inhibiendo su actividad enzimática.

Chymostatin

9076-44-2sc-202541
sc-202541A
sc-202541B
sc-202541C
sc-202541D
5 mg
10 mg
25 mg
50 mg
100 mg
$156.00
$260.00
$640.00
$1186.00
$2270.00
3
(1)

La quimostatina es un inhibidor competitivo de serina proteasas similares a la quimotripsina. Inhibe la PRB1 al unirse a su sitio activo, impidiendo la escisión del sustrato.

AEBSF hydrochloride

30827-99-7sc-202041
sc-202041A
sc-202041B
sc-202041C
sc-202041D
sc-202041E
50 mg
100 mg
5 g
10 g
25 g
100 g
$65.00
$122.00
$428.00
$851.00
$1873.00
$4994.00
33
(1)

AEBSF es un inhibidor irreversible de serina proteasas que reacciona con el residuo de serina en el sitio activo de PRB1, inhibiendo así su actividad proteasa.

E-64

66701-25-5sc-201276
sc-201276A
sc-201276B
5 mg
25 mg
250 mg
$281.00
$947.00
$1574.00
14
(0)

El E-64 es un potente inhibidor de las cisteína proteasas; sin embargo, puede inhibir la PRB1 reaccionando con la cisteína de su sitio activo, si está presente, o modificando los aminoácidos cercanos que influyen en la conformación del sitio activo.

Gabexate mesylate

56974-61-9sc-215066
5 mg
$100.00
(0)

El mesilato de gabexato es un inhibidor sintético de la proteasa que inhibe las serina proteasas como la PRB1 al unirse a la serina del sitio activo, impidiendo así el acceso del sustrato.

Nafamostat mesylate

82956-11-4sc-201307
sc-201307A
10 mg
50 mg
$82.00
$306.00
4
(1)

El mesilato de nafamostat es un inhibidor de serina proteasa de amplio espectro que se une a PRB1 e inhibe su actividad bloqueando el sitio activo.