IBA2 is a protein encoded by the PLEKHM1P gene in humans. This gene is also known as "IBA2 pseudogene," indicating that it is a non-functional copy of a gene. Pseudogenes arise from the duplication or mutation of existing genes, and they typically do not produce functional proteins due to accumulated mutations or alterations in their sequences.However, the original functional gene related to IBA2, from which the pseudogene is derived, has significance in biological research. IBA2 generally refers to "Ionized calcium-Binding Adapter molecule 2," which is involved in various cellular processes, particularly in the immune and nervous systems.
In its functional form, IBA2 is known to be involved in the modulation of calcium signaling within cells. Calcium ions are crucial secondary messengers in cellular signaling pathways, influencing processes such as neurotransmission, muscle contraction, and immune responses. Proteins like IBA2 that bind to calcium ions play critical roles in regulating these processes.IBA2 has been particularly studied in the context of the nervous system and immune system. In the nervous system, it is involved in neuronal development and function, influencing synaptic plasticity and neurotransmitter release. In the immune system, IBA2 may participate in the regulation of immune cell function, such as in the activation and response of macrophages and other immune cells.The study of IBA2, therefore, contributes to our understanding of calcium-dependent signaling in various physiological processes and the implications of these processes in health and disease.
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| Nombre del producto | NÚMERO DE CAS # | Número de catálogo | Cantidad | Precio | MENCIONES | Clasificación |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Aumenta la concentración de calcio extracelular, influyendo potencialmente en la señalización de calcio mediada por IBA2. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Inhiben la calmodulina, una proteína mensajera que se une al calcio, afectando potencialmente al papel de IBA2 en la señalización del calcio. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Estabiliza los filamentos de actina, influyendo potencialmente en la interacción de IBA2 con el citoesqueleto. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Interrumpe la polimerización de la actina, lo que puede influir indirectamente en el papel de IBA2 en la dinámica de la actina. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Estabiliza los filamentos de actina, podría afectar indirectamente a la función de IBA2 relacionada con la reorganización de la actina. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
Un quelante del calcio, puede modular los niveles de calcio e influir potencialmente en la actividad de IBA2. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
Otro quelante del calcio, utilizado para fijar específicamente iones de calcio, que pueden afectar a IBA2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibe la Ca2+ ATPasa del retículo sarcoplásmico/endoplásmico (SERCA), alterando la dinámica del calcio, afectando a la IBA2. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Aumenta la concentración de calcio intracelular, influyendo potencialmente en la actividad de IBA2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Un ionóforo de calcio, puede aumentar el calcio intracelular, afectando posiblemente a IBA2. | ||||||