TROY Antibody (A-9): sc-515473

TROY Antibody (A-9) is a mouse monoclonal IgG2a antibody that detects TROY in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TROY, a member of the tumor necrosis factor receptor (TNFR) superfamily, plays a crucial role in cellular signaling, particularly in cell survival and apoptosis. TROY protein is primarily located in the cell membrane, where TROY functions as a type I transmembrane glycoprotein, facilitating interactions with various intracellular signaling molecules. TROY expression in the epithelium of tissues such as the brain, heart, lung, and liver underscores TROY′s importance in developmental processes and tissue homeostasis. TROY′s cytoplasmic tail is essential for recruiting tumor necrosis factor receptor-associated factor 2 (TRAF2), which subsequently activates the NFkB signaling pathway, promoting cell survival. TROY′s ability to exist in multiple isoforms, including a truncated version known as TNFRSF19, highlights TROY′s functional diversity; while full-length TROY supports cell survival, TNFRSF19 lacks the capacity to activate NFkB, illustrating the intricate balance of signaling pathways that TROY regulates. anti-TROY antibody (A-9) is an invaluable tool for researchers investigating TROY′s complex roles in cellular processes and disease mechanisms.

The preferred TROY antibody is TROY Antibody (D-4): sc-398526.