Troponin C slow skeletal/cardiac Antibody (1A2): sc-52264

Troponin C slow skeletal/cardiac Antibody (1A2) is a mouse monoclonal IgG2a antibody that detects Troponin C in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Troponin C plays a critical role in muscle contraction by serving as a calcium sensor, which is essential for the regulation of muscle function. Troponin C slow skeletal/cardiac (1A2) antibody targets proteins located in the thin filaments of striated muscle, where Troponin C binds calcium ions, leading to conformational changes that facilitate the interaction between actin and myosin, the two primary proteins responsible for muscle contraction. The ability of Troponin C to bind calcium is vital, as this binding triggers the contraction process in both slow skeletal and cardiac muscle fibers, allowing for precise control of heartbeats and muscle movements. Notably, Troponin C exists in two isoforms—fast and slow—each with distinct calcium-binding properties that adapt to the specific functional demands of different muscle types. The slow/cardiac isoform, which has a single calcium-binding site, is particularly important in cardiac muscle, where Troponin C helps regulate the heart′s contraction strength and rhythm. Anti-Troponin C slow skeletal/cardiac antibody (1A2) serves as an invaluable tool for researchers studying muscle physiology and pathophysiology, providing insights into the mechanisms underlying muscle contraction and the role of calcium signaling in health and disease.

The preferred Troponin C fast skeletal antibody is Troponin C fast skeletal Antibody (E-7): sc-48347.