Treponema pallidum Antibody (2121): sc-58204

Treponema pallidum Antibody (2121) is a mouse monoclonal IgG2b antibody that detects Treponema pallidum protein by western blotting (WB) and immunofluorescence (IF). Anti-Treponema pallidum antibody (2121) is available as a non-conjugated format. Treponema pallidum is a Gram-negative spirochaete bacterium characterized by its unique helical shape and periplasmic flagella, which contribute to motility. This motility is crucial for navigating through viscous host tissues, facilitating invasion and colonization. The bacterium causes several diseases, including syphilis, yaws, pinta, and bejel, each associated with different subspecies. Treponema pallidum′s ability to evade host immune response is partly attributed to limited metabolic capabilities and genome size, which is one of the smallest among bacteria at just 1.14 million base pairs. This adaptation allows survival in complex mammalian tissues, where transmission occurs through close sexual contact or from mother to fetus during pregnancy, leading to congenital syphilis. Anti-Treponema pallidum antibody (2121) serves as an essential tool for researchers studying pathogenic mechanisms and host immune system interactions.

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Treponema pallidum Antibody (2121) References:

1. Redox-dependent structural changes in the superoxide reductase from Desulfoarculus baarsii and Treponema pallidum: a FTIR study.  |  Berthomieu, C., et al. 2002. Biochemistry. 41: 10360-8. PMID: 12162752
2. Susceptibility of Treponema pallidum to host-derived antimicrobial peptides.  |  Cox, DL., et al. 2003. Peptides. 24: 1741-6. PMID: 15019205
3. Evaluation of a new particle gel immunoassay for determination of antibodies against Treponema pallidum.  |  Schmidt, BL. 2004. J Clin Microbiol. 42: 2833-5. PMID: 15184485
4. [Seroprevalence of antibodies against Treponema pallidum, Toxoplasma gondii, rubella virus, hepatitis B and C virus, and HIV in pregnant women].  |  Gutiérrez-Zufiaurre, N., et al. 2004. Enferm Infecc Microbiol Clin. 22: 512-6. PMID: 15511391
5. Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis.  |  Aktas, G., et al. 2005. Int J STD AIDS. 16: 294-8. PMID: 15899082
6. Defining the interaction of the Treponema pallidum adhesin Tp0751 with laminin.  |  Cameron, CE., et al. 2005. Infect Immun. 73: 7485-94. PMID: 16239550
7. The centenary of treponema pallidum: on the discovery of Spirochaeta pallida.  |  Waugh, M. 2005. Skinmed. 4: 313-5. PMID: 16282755
8. Treponema pallidum macrolide resistance in BC.  |  Morshed, MG. and Jones, HD. 2006. CMAJ. 174: 349. PMID: 16446481
9. Superoxide reductase from the syphilis spirochete Treponema pallidum: crystallization and structure determination using soft X-rays.  |  Santos-Silva, T., et al. 2005. Acta Crystallogr Sect F Struct Biol Cryst Commun. 61: 967-70. PMID: 16511209

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Treponema pallidum Antibody (2121) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Treponema pallidum Antibody (2121) Specifications

Alternate Product Name: Treponema pallidum

Product Clone Name: 2121

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Treponema pallidum

Epitope Species: Treponema pallidum

Product Reactivity/Detection: Treponema pallidum

Species Reactivity/Detection: Treponema pallidum

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Treponema pallidum Antibody (2121): N/A