TLR4 Antibody (HTA125): sc-13593
- TLR4 Antibody (HTA125) is a mouse monoclonal IgG2a κ, cited in 80 publications, provided at 200 µg/ml
- raised against Toll-like receptor 4 (TLR4)
- TLR4 Antibody (HTA125) is recommended for detection of TLR4/MD-2 complex of human origin by IP, IF, IHC(P) and FCM
- Anti-TLR4 Antibody (HTA125) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for biological studies, sc-13593 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TLR4 Antibody (HTA125) for IHC(P) applications. These reagents are now offered in bundles with TLR4 Antibody (HTA125) (see ordering information below).
TLR4 Antibody (HTA125) is a mouse monoclonal IgG2a kappa light chain antibody that detects the TLR4/MD-2 complex of human origin by immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). TLR4 (HTA125) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TLR4 plays a crucial role in the innate immune system by recognizing lipopolysaccharides (LPS) from Gram-negative bacteria, which triggers a signaling cascade that leads to the activation of nuclear factor kappa B (NFkB) and the subsequent production of pro-inflammatory cytokines. This function is vital for initiating an effective immune response and maintaining homeostasis during infections. TLR4 is primarily located on the surface of immune cells such as macrophages and dendritic cells, where TLR4 acts as a sentinel for pathogen detection. Proper functioning of TLR4 is essential for the host′s ability to respond to infections, and dysregulation of TLR4 signaling has been implicated in various inflammatory diseases and conditions, highlighting TLR4′s importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TLR4 Antibody (HTA125) | sc-13593 | 200 µg/ml | $322.00 | |||
TLR4 Antibody (HTA125): m-IgG Fc BP-HRP Bundle | sc-525482 | 200 µg Ab; 10 µg BP | $361.00 | |||
TLR4 Antibody (HTA125): m-IgG2a BP-HRP Bundle | sc-546279 | 200 µg Ab; 10 µg BP | $361.00 | |||
TLR4 Antibody (HTA125) L | sc-13593 L | 200 µg/0.1 ml | $322.00 | |||
TLR4 Antibody (HTA125) AC | sc-13593 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TLR4 Antibody (HTA125) HRP | sc-13593 HRP | 200 µg/ml | $322.00 | |||
TLR4 Antibody (HTA125) FITC | sc-13593 FITC | 200 µg/ml | $336.00 | |||
TLR4 Antibody (HTA125) PE | sc-13593 PE | 200 µg/ml | $349.00 | |||
TLR4 Antibody (HTA125) Alexa Fluor® 488 | sc-13593 AF488 | 200 µg/ml | $364.00 | |||
TLR4 Antibody (HTA125) Alexa Fluor® 546 | sc-13593 AF546 | 200 µg/ml | $364.00 | |||
TLR4 Antibody (HTA125) Alexa Fluor® 594 | sc-13593 AF594 | 200 µg/ml | $364.00 | |||
TLR4 Antibody (HTA125) Alexa Fluor® 647 | sc-13593 AF647 | 200 µg/ml | $364.00 | |||
TLR4 Antibody (HTA125) Alexa Fluor® 680 | sc-13593 AF680 | 200 µg/ml | $364.00 | |||
TLR4 Antibody (HTA125) Alexa Fluor® 790 | sc-13593 AF790 | 200 µg/ml | $364.00 |