TIP60 Antibody (T4D2): sc-81757
- TIP60 Antibody (T4D2) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant TIP60 of human origin
- recommended for detection of TIP60 of human origin by WB, IF and IHC(P)
- See TIP60 (C-7): sc-166323 for TIP60 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TIP60 Antibody (T4D2) for WB and IHC(P) applications. These reagents are now offered in bundles with TIP60 Antibody (T4D2) (see ordering information below).
QUICK LINKS
SEE ALSO...
TIP60 Antibody (T4D2) is a mouse monoclonal IgG2b antibody that detects TIP60 in human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. TIP60, also known as TAT-interacting protein 60, is a crucial chromatin-associated protein that functions as a histone acetyltransferase (HAT), playing a significant role in the regulation of gene expression and chromatin remodeling. anti-TIP60 antibody (T4D2) recognizes a protein that modifies histones through acetylation, which alters chromatin structure and accessibility, thereby influencing transcriptional activation. TIP60 is particularly notable for its interactions with various transcriptional coactivators and nuclear hormone receptors, enhancing the transcriptional response to steroid hormones such as androgens, estrogens, and progestins. Additionally, TIP60 has been implicated in DNA damage response pathways, where TIP60 acts as a coactivator for the HIV TAT protein and is involved in the recruitment of repair factors to sites of DNA damage. TIP60 (T4D2) antibody is an essential tool for researchers studying the intricate mechanisms of gene regulation and the role of histone modifications in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TIP60 Antibody (T4D2) References:
- Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. | Li, TY., et al. 2018. Nat Commun. 9: 1916. PMID: 29765047
- TIP60 represses activation of endogenous retroviral elements. | Rajagopalan, D., et al. 2018. Nucleic Acids Res. 46: 9456-9470. PMID: 30053221
- Quantifying Tip60 (Kat5) stratifies breast cancer. | McGuire, A., et al. 2019. Sci Rep. 9: 3819. PMID: 30846725
- PRMT5 and Tip60 Modify FOXP3 Function in Tumor Immunity. | Goel, PN., et al. 2020. Crit Rev Immunol. 40: 283-295. PMID: 33426818
- O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis. | Liu, R., et al. 2021. Oncogene. 40: 6707-6719. PMID: 34650217
- Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization. | Niedzialkowska, E., et al. 2022. Mol Biol Cell. 33: br15. PMID: 35653296
- FAM135B sustains the reservoir of Tip60-ATM assembly to promote DNA damage response. | Zhang, K., et al. 2022. Clin Transl Med. 12: e945. PMID: 35979619
- Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease. | Bhatnagar, A., et al. 2023. J Neurosci. 43: 2398-2423. PMID: 36849418
- SPIN1 facilitates chemoresistance and HR repair by promoting Tip60 binding to H3K9me3. | Wang, Y., et al. 2024. EMBO Rep. 25: 3970-3989. PMID: 39090319
- Structure of the human TIP60-C histone exchange and acetyltransferase complex. | Li, C., et al. 2024. Nature. 635: 764-769. PMID: 39260417
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIP60 Antibody (T4D2) | sc-81757 | 200 µg/ml | $322.00 | |||
TIP60 Antibody (T4D2): m-IgGκ BP-HRP Bundle | sc-534487 | 200 µg Ab; 40 µg BP | $361.00 | |||
TIP60 Antibody (T4D2): m-IgG2b BP-HRP Bundle | sc-549261 | 200 µg Ab; 10 µg BP | $361.00 |