TIP60 Antibody (3F9G7): sc-81164
- TIP60 Antibody (3F9G7) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 18-208 of TIP60 of human origin
- recommended for detection of TIP60 of human origin by WB, IF and IHC(P)
- See TIP60 (C-7): sc-166323 for TIP60 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TIP60 Antibody (3F9G7) for WB and IHC(P) applications. These reagents are now offered in bundles with TIP60 Antibody (3F9G7) (see ordering information below).
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TIP60 Antibody (3F9G7) is a mouse monoclonal IgG2b antibody that detects TIP60 in human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. TIP60, also known as TAT-interacting protein 60, is a crucial chromatin-associated protein that functions as a histone acetyltransferase (HAT) and plays a significant role in regulating gene expression and DNA repair mechanisms. Anti-TIP60 antibody (3F9G7) recognizes a protein essential for acetylating histones and non-histone proteins, vital for modulating chromatin structure and influencing transcriptional activation and repression. TIP60 is particularly important in cellular responses to stress and DNA damage, as TIP60 is involved in recruiting repair factors to damage sites, facilitating efficient repair processes. Additionally, TIP60 interacts with various proteins, including nuclear hormone receptors, enhancing their transcriptional activity, which underscores TIP60′s role in steroid hormone signaling pathways. TIP60′s presence and functional interactions are critical for maintaining cellular homeostasis and responding to environmental cues, making TIP60 a key player in both normal physiology and disease states, including cancer. With specificity and versatility, TIP60 (3F9G7) antibody serves as an essential tool for researchers investigating the intricate mechanisms of gene regulation and chromatin dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TIP60 Antibody (3F9G7) References:
- Cellular functions of TIP60. | Sapountzi, V., et al. 2006. Int J Biochem Cell Biol. 38: 1496-509. PMID: 16698308
- TIP60 in aging and neurodegeneration. | Li, Z. and Rasmussen, LJ. 2020. Ageing Res Rev. 64: 101195. PMID: 33091598
- TIP60 buffers acute stress response and depressive behaviour by controlling PPARγ-mediated transcription. | Wang, B., et al. 2022. Brain Behav Immun. 101: 410-422. PMID: 35114329
- Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation. | Janas, JA., et al. 2022. Mol Cell. 82: 4627-4646.e14. PMID: 36417913
- TIP60 is required for tumorigenesis in non-small cell lung cancer. | Shibahara, D., et al. 2023. Cancer Sci. 114: 2400-2413. PMID: 36916958
- The structure of the NuA4-Tip60 complex reveals the mechanism and importance of long-range chromatin modification. | Fréchard, A., et al. 2023. Nat Struct Mol Biol. 30: 1337-1345. PMID: 37550452
- TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release. | Wang, Y., et al. 2023. Clin Exp Hypertens. 45: 2259130. PMID: 37817460
- EP400/TIP60 compensates for SWI/SNF loss. | Faial, T. 2023. Nat Genet. 55: 2018. PMID: 38062102
- Small-molecule TIP60 inhibitors enhance regulatory T cell induction through TIP60-P300 acetylation crosstalk. | Fueyo-González, F., et al. 2023. iScience. 26: 108491. PMID: 38094248
- Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. | Yang, Z., et al. 2024. Science. 385: eadl5816. PMID: 39088653
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIP60 Antibody (3F9G7) | sc-81164 | 200 µg/ml | $322.00 | |||
TIP60 Antibody (3F9G7): m-IgGκ BP-HRP Bundle | sc-534461 | 200 µg Ab; 40 µg BP | $361.00 | |||
TIP60 Antibody (3F9G7): m-IgG2b BP-HRP Bundle | sc-549259 | 200 µg Ab; 10 µg BP | $361.00 |