TALL-1 Antibody (A-9): sc-271809
- TALL-1 Antibody (A-9) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 253-277 at the C-terminus of TALL-1 of human origin
- recommended for detection of TALL-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TALL-1 Antibody (A-9). This work is in progress.
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TALL-1 Antibody (A-9) is a mouse monoclonal IgM antibody that detects TALL-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TALL-1, also known as BAFF, THANK, and BLyS, is a type II membrane protein belonging to the tumor necrosis factor (TNF) cytokine family, and plays a pivotal role in immune regulation. TALL-1 is predominantly expressed in peripheral blood leukocytes, monocytes, and macrophages, where TALL-1 is essential for modulating infections, inflammation, autoimmune diseases, and tissue homeostasis. TALL-1 functions as a potent B cell stimulatory factor, significantly influencing B cell proliferation and serving as a key mediator in B cell-associated autoimmune disorders. TALL-1′s structure features a C-terminal extracellular domain with a jelly roll topography, which is crucial for ligand trimerization. The interaction between TALL-1 and its receptor triggers oligomerization, leading to the initiation of downstream signaling pathways. This oligomerization process is vital as TALL-1 forms the receptor binding site at the junction of adjacent subunits, resulting in a multivalent ligand that enhances signaling capacity, thereby amplifying biological effects in the immune response.
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TALL-1 Antibody (A-9) References:
- TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. | Shu, HB., et al. 1999. J Leukoc Biol. 65: 680-3. PMID: 10331498
- Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. | Xu, LG., et al. 2002. J Leukoc Biol. 72: 410-6. PMID: 12149433
- TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. | Xu, LG. and Shu, HB. 2002. J Immunol. 169: 6883-9. PMID: 12471121
- TNF ligands: is TALL-1 a trimer or a virus-like cluster? | Zhukovsky, EA., et al. 2004. Nature. 427: 413-4; discussion 414. PMID: 14749821
- Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells. | Palchetti, S., et al. 2017. Nanomedicine. 13: 681-691. PMID: 27565691
- The depletion of PHF6 decreases the drug sensitivity of T-cell acute lymphoblastic leukemia to prednisolone. | Xiang, J., et al. 2019. Biomed Pharmacother. 109: 2210-2217. PMID: 30551478
- Establishment of a T-cell line from human lymphosarcoma. | Hiraki, S., et al. 1978. Gan. 69: 115-8. PMID: 305872
- Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells. | Siqueira, RP., et al. 2020. Toxicol In Vitro. 65: 104777. PMID: 31962201
- Too Tall for the DXA Scan? Contributions of the Feet and Head to Overall Body Composition. | Hew-Butler, T., et al. 2022. J Clin Densitom. 25: 384-391. PMID: 34969607
- Human immunodeficiency virus type-1 envelope glycoprotein gp120 induces expression of fusion regulatory protein (FRP)-1/CD98 on CD4+ T cells: a possible regulatory mechanism of HIV-induced syncytium formation. | Suga, S., et al. 1997. Med Microbiol Immunol. 185: 237-43. PMID: 9138296
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TALL-1 Antibody (A-9) | sc-271809 | 200 µg/ml | $322.00 | |||
TALL-1 (A-9) Neutralizing Peptide | sc-271809 P | 100 µg/0.5 ml | $69.00 |