Talin Antibody (A-11): sc-365460
- Talin Antibody (A-11) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2517-2540 at the C-terminus of Talin of human origin
- recommended for detection of Talin-1 and Talin-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and bovine
- See Talin (C-9): sc-365875 for Talin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Talin Antibody (A-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with Talin Antibody (A-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Talin Antibody (A-11) is a mouse monoclonal IgG3 antibody that recognizes Talin in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Talin plays a crucial role in linking integrins to the actin cytoskeleton, which is essential for cell adhesion and signaling processes. Talin is primarily located at focal adhesions, specialized structures that form at the interface between cells and the extracellular matrix. Anti-Talin antibody (A-11) helps detect Talin at these sites, where the protein regulates cell shape, motility, and mechanical signal transmission - important factors for tissue integrity and cellular communication. Talin interacts with other cytoskeletal proteins, such as vinculin and α-actinin, facilitating the assembly of focal adhesion complexes that stabilize cell attachment and promote cellular responses to external stimuli. Dynamic regulation of Talin′s activity and interactions with other proteins are critical for maintaining cellular functions and responding to changes in the extracellular environment, making Talin a key player in various physiological and pathological processes. Talin (A-11) antibody serves as an invaluable tool for researchers studying cell adhesion mechanisms and their implications in health and disease.
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Talin Antibody (A-11) References:
- The tail of integrins, talin, and kindlins. | Moser, M., et al. 2009. Science. 324: 895-9. PMID: 19443776
- Talin determines the nanoscale architecture of focal adhesions. | Liu, J., et al. 2015. Proc Natl Acad Sci U S A. 112: E4864-73. PMID: 26283369
- Vinculin controls talin engagement with the actomyosin machinery. | Atherton, P., et al. 2015. Nat Commun. 6: 10038. PMID: 26634421
- Kindlin Assists Talin to Promote Integrin Activation. | Haydari, Z., et al. 2020. Biophys J. 118: 1977-1991. PMID: 32191864
- Talin-1; other than a potential marker for hepatocellular carcinoma diagnosis. | Aboelfotoh, AO., et al. 2020. Arab J Gastroenterol. 21: 80-84. PMID: 32439236
- Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force. | Vigouroux, C., et al. 2020. Nat Commun. 11: 3116. PMID: 32561773
- Talin folding as the tuning fork of cellular mechanotransduction. | Tapia-Rojo, R., et al. 2020. Proc Natl Acad Sci U S A. 117: 21346-21353. PMID: 32817549
- Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction. | Fong, KP., et al. 2021. Blood Adv. 5: 4901-4909. PMID: 34570183
- KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner. | Zhang, C., et al. 2022. Arterioscler Thromb Vasc Biol. 42: 772-788. PMID: 35477278
- Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease. | Aoyama, M., et al. 2022. Med Sci (Basel). 10: PMID: 36135831
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Talin Antibody (A-11) | sc-365460 | 200 µg/ml | $322.00 | |||
Talin Antibody (A-11): m-IgGκ BP-HRP Bundle | sc-522248 | 200 µg Ab, 40 µg BP | $361.00 | |||
Talin (A-11) Neutralizing Peptide | sc-365460 P | 100 µg/0.5 ml | $69.00 |