T-Plastin Antibody (A-8): sc-166223
- T-Plastin Antibody (A-8) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 482-516 at the N-terminus of T-Plastin of human origin
- recommended for detection of T-Plastin of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, porcine and avian
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for T-Plastin Antibody (A-8) for WB applications. These reagents are now offered in bundles with T-Plastin Antibody (A-8) (see ordering information below).
T-Plastin Antibody (A-8) is a mouse monoclonal IgG2b light chain antibody that detects T-Plastin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). T-Plastin is a member of the plastin family of actin-binding proteins, which play crucial roles in cytoskeletal organization and cellular dynamics. T-Plastin is expressed in a variety of tissues, distinguishing itself from L-Plastin, which is primarily found in hematopoietic cells. T-Plastin′s presence in non-leukocyte tissues suggests involvement in diverse cellular functions, including cell shape maintenance and motility. T-Plastin contains multiple actin-binding domains that facilitate interaction with the cytoskeleton, thereby influencing cellular processes such as migration and adhesion. T-Plastin′s activity regulation through post-translational modifications, such as phosphorylation, underscores importance in cellular signaling pathways, particularly in response to external stimuli. Anti-T-Plastin antibody (A-8) enables researchers to gain valuable insights into T-Plastin′s role in various biological contexts, including potential implications in cancer biology and tissue development.
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T-Plastin Antibody (A-8) References:
- Differential regulation of human T-plastin gene in leukocytes and non-leukocytes: identification of the promoter, enhancer, and CpG island. | Lin, CS., et al. 1999. DNA Cell Biol. 18: 27-37. PMID: 10025506
- Changes in T-plastin expression with human trophoblast differentiation. | Rao, RM., et al. 2003. Reprod Biomed Online. 7: 235-42. PMID: 14567899
- Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement. | Giganti, A., et al. 2005. J Cell Sci. 118: 1255-65. PMID: 15741236
- Generation and characterization of monoclonal antibodies that specifically recognize p65/L-plastin isoform but not T-plastin isoform. | Toyooka, K., et al. 2006. Biosci Biotechnol Biochem. 70: 1402-7. PMID: 16794320
- Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. | Capriotti, E., et al. 2008. Leuk Lymphoma. 49: 1190-201. PMID: 18569641
- Interaction of activated Rab5 with actin-bundling proteins, L- and T-plastin and its relevance to endocytic functions in mammalian cells. | Hagiwara, M., et al. 2011. Biochem Biophys Res Commun. 407: 615-9. PMID: 21426900
- Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma. | Jones, CL., et al. 2012. J Invest Dermatol. 132: 2042-9. PMID: 22495182
- Chemical proteomic identification of T-plastin as a novel host cell response factor in HCV infection. | Yoo, YH., et al. 2015. Sci Rep. 5: 9773. PMID: 25909246
- T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway. | Park, SY., et al. 2024. BMB Rep. 57: 305-310. PMID: 38835117
- Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells. | Adam, T., et al. 1995. J Cell Biol. 129: 367-81. PMID: 7721941
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
T-Plastin Antibody (A-8) | sc-166223 | 200 µg/ml | $322.00 | |||
T-Plastin Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-537458 | 200 µg Ab; 10 µg BP | $361.00 | |||
T-Plastin Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-534731 | 200 µg Ab; 40 µg BP | $361.00 | |||
T-Plastin Antibody (A-8): m-IgG2b BP-HRP Bundle | sc-549875 | 200 µg Ab; 10 µg BP | $361.00 | |||
T-Plastin (A-8) Neutralizing Peptide | sc-166223 P | 100 µg/0.5 ml | $69.00 |